公开(公告)号：US20240245682A1

公开(公告)日：2024-07-25

申请号：US18395241

申请日：2023-12-22

申请人： Pliant Therapeutics, Inc.

发明人： Timothy D. MACHAJEWSKI ,  Darren FINKELSTEIN ,  Timothy F. HOM ,  Dennis MONTELEONE ,  Manuel Angel MUNOZ ,  Katerina LEFTHERIS

IPC分类号： A61K31/501 ,  A61K31/337 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7068 ,  A61P35/00 ,  C07D471/04 ,  G01N33/50

CPC分类号： A61K31/501 ,  A61K31/337 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7068 ,  A61P35/00 ,  C07D471/04 ,  G01N33/5011 ,  G01N2333/57 ,  G01N2333/96436

摘要： The disclosure relates to compounds of formula (A) and formula (I), e.g.:




or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, L1, L2, L3, Y, and Q are as described herein. Compounds of formula (A) and formula (I) and pharmaceutical compositions thereof are inhibitors of at least one or more of αVβ8, αVβ1, and αVβ6 integrins. Also disclosed are methods for treating fibrosis such as nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP), and cancer comprising administration of the compounds and pharmaceutical compositions thereof.