公开(公告)号：US20200069648A1

公开(公告)日：2020-03-05

申请号：US16490220

申请日：2018-03-02

Applicant: Pharmaxis Ltd.

Inventor： Alison Dorothy FINDLAY ,  Craig Ivan TURNER ,  Mandar DEODHAR ,  Jonathan Stuart FOOT ,  Wenbin ZHOU ,  Wolfgang JAROLIMEK ,  Alan Duncan ROBERTSON

IPC: A61K31/4155 ,  C07D231/12 ,  A61K31/415 ,  C07D231/14 ,  C07D231/16 ,  A61K45/06 ,  A61P1/16 ,  A61K31/5377 ,  C07D231/18 ,  C07D401/06 ,  A61K31/4439

Abstract: The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

公开(公告)号：US20210353571A1

公开(公告)日：2021-11-18

申请号：US17265402

申请日：2019-08-02

Applicant: Pharmaxis Ltd.

Inventor： Alison Dorothy FINDLAY ,  Craig Ivan TURNER ,  Mandar DEODHAR ,  Jonathan Stuart FOOT ,  Wolfgang JAROLIMEK ,  Wenbin ZHOU ,  Alberto BUSON ,  Angelique Elsa GRECO

IPC: A61K31/18 ,  A61P17/02 ,  A61P35/00 ,  A61P19/04 ,  A61P35/04 ,  C07C311/29 ,  C07C317/32 ,  C07D213/71 ,  C07D215/36 ,  C07D277/64 ,  C07D209/08 ,  A61K31/145 ,  A61K31/4409 ,  A61K31/47

Abstract: The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.