公开(公告)号：US20230167080A1

公开(公告)日：2023-06-01

申请号：US18060027

申请日：2022-11-30

申请人： Pfizer Inc.

发明人： Leanne Marie BUZON ,  Kimberly O'Keefe CAMERON ,  Kevin Francis DEBOYACE ,  Kevin James FILIPSKI ,  David Andrew GRIFFITH ,  Bethany Lyn KORMOS ,  Shenping LIU ,  Luis Angel MARTINEZ ALSINA ,  Matthew Richard REESE ,  Rachel Jane ROTH FLACH ,  Yuan ZHANG

IPC分类号： C07D333/68 ,  A61P3/04 ,  A61P9/00

CPC分类号： C07D333/68 ,  A61P3/04 ,  A61P9/00 ,  C07B2200/13

摘要： Described herein are compounds of Formula I,




wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NASH and heart failure.