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1.发明申请AXIALLY ANCHORING COLLAPSIBLE AND RE-EXPANDABLE PROSTHETIC HEART VALVES FOR VARIOUS DISEASE STATES 有权对各种疾病状态进行轴向锚定和可再膨胀的预防心脏瓣膜公开(公告)号：US20110098800A1
公开(公告)日：2011-04-28
申请号：US12737254
申请日：2009-07-15
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A stent (10) for use in a prosthetic heart valve has an annulus section (12) adapted for placement within the leaflets and annulus of the native heart valve. The annulus section has latch members (50) adapted to engage the leaflets of the native heart valve when prosthetic valve is implanted in the native valve. The latch members may hold the leaflets in engagement with the annulus section, and help to retain the prosthetic valve in position. The annulus section may have a non-circular cross-sectional shape.
摘要翻译： 用于假体心脏瓣膜的支架（10）具有适于放置在天然心脏瓣膜的瓣叶和环状物中的环形部分（12）。 环形部分具有闩锁构件（50），当人工瓣膜植入天然瓣膜时，该构件适于接合天然心脏瓣膜的小叶。 闩锁构件可以将小叶保持与环形部分接合，并且有助于将假体瓣保持在适当位置。 环形部分可以具有非圆形横截面形状。
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公开(公告)号：US20120078347A1
公开(公告)日：2012-03-29
申请号：US13203627
申请日：2010-02-25
申请人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
发明人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
CPC分类号： A61F2/2418 , A61F2/915 , A61F2002/91575 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
摘要翻译： 假体心脏瓣膜包括具有扩张状态和折叠状态的支架。 支架包括多个远端细胞，多个近端细胞，将近端细胞耦合到远端细胞的多个支撑支柱以及连接到多个近端细胞的至少一个支撑柱。 近端细胞与远端细胞纵向间隔开。 支柱结构和连接到近端细胞和近端细胞到支撑柱的各种支柱构型和连接可改善支架的灵活性并减少瓣膜小叶中的压力。
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3.发明授权Axially anchoring collapsible and re-expandable prosthetic heart valves for various disease states 有权用于各种疾病状态的轴向锚固可折叠和可再膨胀的假性心脏瓣膜公开(公告)号：US09226820B2
公开(公告)日：2016-01-05
申请号：US12737254
申请日：2009-07-15
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008
摘要： A stent (10) for use in a prosthetic heart valve has an annulus section (12) adapted for placement within the ′ leaflets and annulus of the native heart valve. The annulus section has latch members (50) adapted to engage the leaflets of the native heart valve when prosthetic valve is implanted in the native valve. The latch members may hold the leaflets in engagement with the annulus section, and help to retain the prosthetic valve in position. The annulus section may have a non-circular cross-sectional shape.
摘要翻译： 用于假体心脏瓣膜的支架（10）具有适于放置在天然心脏瓣膜的小叶和环形空间内的环形部分（12）。 环形部分具有闩锁构件（50），当人工瓣膜植入天然瓣膜时，该构件适于接合天然心脏瓣膜的小叶。 闩锁构件可以将小叶保持与环形部分接合，并且有助于将假体瓣保持在适当位置。 环形部分可以具有非圆形横截面形状。
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公开(公告)号：US08808366B2
公开(公告)日：2014-08-19
申请号：US13203627
申请日：2010-02-25
申请人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
发明人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/915 , A61F2002/91575 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
摘要翻译： 假体心脏瓣膜包括具有扩张状态和折叠状态的支架。 支架包括多个远端细胞，多个近端细胞，将近端细胞耦合到远端细胞的多个支撑支柱以及连接到多个近端细胞的至少一个支撑柱。 近端细胞与远端细胞纵向间隔开。 支柱结构和连接到近端细胞和近端细胞到支撑柱的各种支柱构型和连接可改善支架的灵活性并减少瓣膜小叶中的压力。
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5.发明授权Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications 有权可折叠和可重新扩张的假体心脏瓣膜袖口设计和补充技术应用公开(公告)号：US08808356B2
公开(公告)日：2014-08-19
申请号：US12737256
申请日：2009-07-15
CPC分类号： A61F2/2409 , A61F2/01 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/2442 , A61F2/246 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61F2250/0039 , A61F2250/0069
摘要： A prosthetic heart valve is provided with a cuff having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion adapted to bear on the LVOT when the valve is implanted in a native aortic valve. The valve may include elements for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part of the cuff may be movable relative to the stent during implantation.
摘要翻译： 假体心脏瓣膜设置有具有促进与天然组织密封的特征的袖带，即使天然组织是不规则的。 当瓣膜植入天然主动脉瓣中时，套囊可以包括适于承受LVOT的部分。 当支架主体处于膨胀状态时，阀可以包括用于相对于支架主体向外偏压套囊的元件。 袖带可以具有以与由天然组织限定的开口的形状相匹配的图案围绕阀的圆周分布的不同厚度的部分。 在植入期间，全部或部分袖带可相对于支架移动。
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公开(公告)号：US08425593B2
公开(公告)日：2013-04-23
申请号：US12733759
申请日：2008-09-26
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2403 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/89 , A61F2220/0008 , A61F2220/0075 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069
摘要： Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.
摘要翻译： 假体心脏瓣膜可折叠到相对较小的圆周尺寸以便较少侵入性地输送到患者体内，然后在患者的植入部位再扩张至操作尺寸，包括可折叠/可扩张的支架状支撑结构和各种部件 柔性的片状材料，其附接到支撑结构。 例如，这些片状的其他部件可以包括假体瓣膜小叶，缓冲材料层，袖带材料等。提供了改进的结构和技术，用于将这些其它部件固定到瓣膜的支架状支撑结构上。
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7.发明申请公开(公告)号：US20110098802A1
公开(公告)日：2011-04-28
申请号：US12737256
申请日：2009-07-15
CPC分类号： A61F2/2409 , A61F2/01 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/2442 , A61F2/246 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61F2250/0039 , A61F2250/0069
摘要： A prosthetic heart valve is provided with a cuff (85, 285, 400) having features which promote sealing with the native tissues even where the native tissues are irregular. The cuff may include a portion (90) adapted to bear native aortic valve. The valve may include elements (210, 211, 230, 252, 253) for biasing the cuff outwardly with respect to the stent body when the stent body is in an expanded condition. The cuff may have portions of different thickness (280) distributed around the circumference of the valve in a pattern matching the shape of the opening defined by the native tissue. All or part (402) of the cuff may be movable relative to the stent during implantation.
摘要翻译： 假体心脏瓣膜具有袖带（85,285,400），其具有促进与天然组织密封的特征，即使天然组织是不规则的。 袖带可以包括适于承载原生主动脉瓣的部分（90）。 当支架主体处于膨胀状态时，阀可以包括用于相对于支架主体向外偏压套囊的元件（210,211,230,252,253）。 袖带可以具有以与天然组织限定的开口的形状相匹配的图案围绕阀的圆周分布的不同厚度（280）的部分。 袖带的全部或部分（402）在植入期间可相对于支架移动。
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公开(公告)号：US20100185277A1
公开(公告)日：2010-07-22
申请号：US12733759
申请日：2008-09-26
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2403 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2/89 , A61F2220/0008 , A61F2220/0075 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069
摘要： Prosthetic heart valves, which are collapsible to a relatively small circumferential size for less invasive delivery into a patient and which then re-expand to operating size at an implant site in the patient, include a collapsible/expandable stent-like supporting structure and various components of flexible, sheet-like material that are attached to the supporting structure. For example, these sheet-like other components may include prosthetic valve leaflets, layers of buffering material, cuff material, etc. Improved structures and techniques are provided for securing such other components to the stent-like supporting structure of the valve.
摘要翻译： 假体心脏瓣膜可折叠到相对较小的圆周尺寸以便较少侵入性地输送到患者体内，然后在患者的植入部位再扩张至操作尺寸，包括可折叠/可扩张的支架状支撑结构和各种部件 柔性的片状材料，其附接到支撑结构。 例如，这些片状的其他部件可以包括假体瓣膜小叶，缓冲材料层，袖带材料等。提供了改进的结构和技术，用于将这些其它部件固定到瓣膜的支架状支撑结构上。
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公开(公告)号：US09572660B2
公开(公告)日：2017-02-21
申请号：US12451678
申请日：2008-06-04
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译： 假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。 折叠状态可以用于将瓣膜侵入性较差的患者。 当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。 所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。 当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。
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公开(公告)号：US20100160832A1
公开(公告)日：2010-06-24
申请号：US12340382
申请日：2008-12-19
申请人： Peter N. Braido
发明人： Peter N. Braido
IPC分类号： A61B5/107
CPC分类号： A61B5/1076 , A61B5/02007 , A61B5/6876 , A61B5/6884
摘要： An apparatus comprising a blood vessel measuring device is disclosed. The blood vessel measuring device may comprise a handle. A measuring member may be attached to the handle. The measuring member may be dimensioned to wrap around a blood vessel to measure a size of the blood vessel. The blood vessel measuring device may comprise an extension, and a first end of the extension may be attached to the handle. The blood vessel measuring device may comprise a connector attached to a second end of the extension. A method is also disclosed. The method may comprise inserting a measuring device into an incision in a patient. The measuring device may comprise a measuring member. The method may also comprise wrapping the measuring member around a blood vessel of the patient and measuring a dimension of the blood vessel with the measuring member.
摘要翻译： 公开了一种包括血管测量装置的装置。 血管测量装置可以包括手柄。 测量构件可以附接到手柄。 测量构件的尺寸可以围绕血管包围以测量血管的尺寸。 血管测量装置可以包括延伸部，并且延伸部的第一端可以附接到手柄。 血管测量装置可以包括连接到延伸部的第二端的连接器。 还公开了一种方法。 该方法可以包括将测量装置插入患者的切口中。 测量装置可以包括测量构件。 该方法还可以包括将测量构件缠绕在患者的血管周围并用测量构件测量血管的尺寸。
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