公开(公告)号：US20210317150A1

公开(公告)日：2021-10-14

申请号：US17338802

申请日：2021-06-04

申请人： Peloton Therapeutics, Inc.

发明人： Bin Wang ,  Hanbiao Yang ,  Karl Bedke ,  Paul Wehn ,  James P. Rizzi

IPC分类号： C07F9/6561

摘要： Compounds that modulate CD73 activity, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with CD73 activity are described herein.

公开(公告)号：US20210253614A1

公开(公告)日：2021-08-19

申请号：US17056977

申请日：2019-05-31

申请人： Peloton Therapeutics, Inc.

发明人： Bin Wang ,  Hanbiao Yang ,  Karl Bedke ,  James P. Rizzi ,  Heli Huang ,  Keshi Wang

IPC分类号： C07F9/6561 ,  A61K45/06 ,  A61K31/685 ,  A61P35/00 ,  A61K31/675 ,  C07F9/6571

摘要： Compounds that modulate CD73 activity, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with CD73 activity are described herein.

公开(公告)号：US11591355B2

公开(公告)日：2023-02-28

申请号：US17338802

申请日：2021-06-04

申请人： Peloton Therapeutics, Inc.

发明人： Bin Wang ,  Hanbiao Yang ,  Karl Bedke ,  Paul Wehn ,  James P. Rizzi

IPC分类号： C07F9/6561

摘要： The present disclosure provides compounds of Formula (II) wherein R1, R2, R3, R4, R5, W1, W2, W3, X, Y, and A are as described herein. The disclosed compounds modulate CD73 activity. The present disclosure also provides, pharmaceutical compositions containing these compounds, and methods of using these compounds for treating diseases associated with CD73 activity.