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公开(公告)号：US20130209409A1
公开(公告)日：2013-08-15
申请号：US13798784
申请日：2013-03-13
申请人： Paul Harden , Terry Hermiston , Irene Kuhn
发明人： Paul Harden , Terry Hermiston , Irene Kuhn
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/761 , A61K38/45 , C12N15/86 , C12N2710/10021 , C12N2710/10032 , C12N2710/10051 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10344 , A61K2300/00
摘要： The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
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公开(公告)号：US08765463B2
公开(公告)日：2014-07-01
申请号：US13443055
申请日：2012-04-10
申请人： Paul Harden , Terry Hermiston , Irene Kuhn
发明人： Paul Harden , Terry Hermiston , Irene Kuhn
IPC分类号： C12N15/861
CPC分类号： C12N7/00 , A61K35/761 , A61K38/45 , C12N15/86 , C12N2710/10021 , C12N2710/10032 , C12N2710/10051 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10344 , A61K2300/00
摘要： The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
摘要翻译： 本发明涉及具有治疗应用的溶瘤性腺病毒。 提供重组嵌合腺病毒及其生产方法。 本发明的嵌合腺病毒包含衍生自分类在B至F亚组内的腺病毒血清型的核酸序列，并且表现出增强的治疗指数。
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公开(公告)号：US07510868B2
公开(公告)日：2009-03-31
申请号：US11136912
申请日：2005-05-24
申请人： Paul Harden , Terry Hermiston , Irene Kuhn
发明人： Paul Harden , Terry Hermiston , Irene Kuhn
CPC分类号： C12N7/00 , A61K35/761 , A61K38/45 , C12N15/86 , C12N2710/10021 , C12N2710/10032 , C12N2710/10051 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10344 , A61K2300/00
摘要： The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
摘要翻译： 本发明涉及具有治疗应用的溶瘤性腺病毒。 提供重组嵌合腺病毒及其生产方法。 本发明的嵌合腺病毒包含衍生自分类在B至F亚组内的腺病毒血清型的核酸序列，并且表现出增强的治疗指数。
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公开(公告)号：US08158599B2
公开(公告)日：2012-04-17
申请号：US12413748
申请日：2009-03-30
申请人： Paul Harden , Terry Hermiston , Irene Kuhn
发明人： Paul Harden , Terry Hermiston , Irene Kuhn
CPC分类号： C12N7/00 , A61K35/761 , A61K38/45 , C12N15/86 , C12N2710/10021 , C12N2710/10032 , C12N2710/10051 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10344 , A61K2300/00
摘要： The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
摘要翻译： 本发明涉及具有治疗应用的溶瘤性腺病毒。 提供重组嵌合腺病毒及其生产方法。 本发明的嵌合腺病毒包含衍生自分类在B至F亚组内的腺病毒血清型的核酸序列，并且表现出增强的治疗指数。
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公开(公告)号：US20050265973A1
公开(公告)日：2005-12-01
申请号：US11136912
申请日：2005-05-24
申请人： Paul Harden , Terry Hermiston , Irene Kuhn
发明人： Paul Harden , Terry Hermiston , Irene Kuhn
CPC分类号： C12N7/00 , A61K35/761 , A61K38/45 , C12N15/86 , C12N2710/10021 , C12N2710/10032 , C12N2710/10051 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10344 , A61K2300/00
摘要： The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of the invention comprise nucleic acid sequences derived from adenoviral serotypes classified within the subgroups B through F and demonstrate an enhanced therapeutic index.
摘要翻译： 本发明涉及具有治疗应用的溶瘤性腺病毒。 提供重组嵌合腺病毒及其生产方法。 本发明的嵌合腺病毒包含衍生自分类在B至F亚组内的腺病毒血清型的核酸序列，并且证明了增强的治疗指数。
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