公开(公告)号：US20240382559A1

公开(公告)日：2024-11-21

申请号：US18688285

申请日：2022-08-31

Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

Inventor： Jin HUR ,  Jung-Hwa HAN ,  Soo Yong LEE

IPC: A61K38/17 ,  A61K38/10 ,  A61P1/16

Abstract: The KAI1 protein or a fragment thereof according to the present invention inhibited hepatic fibrosis in mice in which acute hepatic fibrosis was induced by CCl4. The KAI1 protein suppressed hepatic fibrosis by inhibiting fibrosis of hepatocytes treated with TGF-β1 and promoting senescence of hepatic stellate cells. Therefore, the pharmaceutical composition comprising the KAI1 protein according to the present invention may be used to effectively prevent or treat hepatic fibrosis.