公开(公告)号：US20180200283A1

公开(公告)日：2018-07-19

申请号：US15742525

申请日：2016-07-08

Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

Inventor： Yuseok MOON ,  Ki Hyung KIM

IPC: A61K31/7105 ,  A61K31/713 ,  A61P35/04 ,  A61K48/00 ,  G01N33/574

Abstract: A pharmaceutical composition includes an NAG-1 inhibitor as an active ingredient for inhibiting resistance against an anticancer drug of an ovarian cancer patient and a method of diagnosing prognosis of resistance against an anticancer drug of an ovarian cancer patient by using the NAG-1 inhibitor. It is found by controlling NAG-1 protein that NAG-1, which is overexpressed in an ovarian cancer patient and in an ovarian cancer stem cell having resistance against an anticancer drug, plays a key role in a chronic inflammatory reaction and resistance against an anticancer drug, and in this regard, NAG-1 can be used as a target gene for effective tumor therapy.