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公开(公告)号：US20250074944A1
公开(公告)日：2025-03-06
申请号：US18796506
申请日：2024-08-07
Inventor： Joongoo LEE , Kanghun LEE
Abstract: Non-canonical substrates-acylated tRNA, introduction of non-canonical substrates into a peptide using ribosome catalysis, and method of preparing pharmacologically active motifs are disclosed. The present invention relates to acylated tRNA and introduction of pharmacologically active motif in peptide using ribosome-mediated catalysis and method that enables the production of a peptide having a cyclic motif without a complicated chemical process on an in vitro protein translation system.
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