公开(公告)号：US20240228598A1

公开(公告)日：2024-07-11

申请号：US18403934

申请日：2024-01-04

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Su Jin NOH ,  Jaewoo AHN

IPC: C07K16/18 ,  A61K47/68 ,  A61P25/18

CPC classification number: C07K16/18 ,  A61K47/6803 ,  A61K47/6843 ,  A61P25/18 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/565 ,  C07K2317/569

Abstract: The present invention relates to a nanobody or an antigen binding fragment thereof, and a pharmaceutical composition for preventing or treating a mental or neurological disease, which includes the nanobody or antigen binding fragment thereof. The nanobody or antigen binding fragment thereof according to the present invention binds to proteins (i.e., C1, C3, or C4) of the complement system to inhibit or interfere with their activity, thereby preventing a decrease in dendritic spines in nerve cells, and thus effectively improving the positive and negative symptoms of schizophrenia. In particular, the nanobody or antigen binding fragment thereof according to the prevent invention has an excellent advantage in that it may improve the negative symptoms of schizophrenia, which were difficult to treat in the past.