公开(公告)号：US20230096841A1

公开(公告)日：2023-03-30

申请号：US17987391

申请日：2022-11-15

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Seulgi HAN ,  Hyun Woo LEE ,  Kyoo KIM

IPC: A61K41/00 ,  C09K11/77 ,  A61K47/69 ,  A61N5/06 ,  C09K11/02 ,  A61K8/02 ,  A61K8/19 ,  A61Q1/02 ,  A61K8/73

Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.

公开(公告)号：US20200276309A1

公开(公告)日：2020-09-03

申请号：US16783548

申请日：2020-02-06

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Seulgi HAN ,  Hyun Woo LEE ,  Kyoo KIM

IPC: A61K41/00 ,  C09K11/77 ,  A61K47/69 ,  A61N5/06 ,  C09K11/02 ,  A61K8/02 ,  A61K8/19 ,  A61Q1/02 ,  A61K8/73

Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.

公开(公告)号：US20190076526A1

公开(公告)日：2019-03-14

申请号：US15703194

申请日：2017-09-13

Applicant: POSCO ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sei Kwang HAHN ,  Seulgi HAN ,  Hyun Woo LEE ,  Kyoo KIM

IPC: A61K41/00 ,  C09K11/02 ,  C09K11/77 ,  A61K47/69 ,  A61N5/06

Abstract: An upconversion nanoparticle includes at least one host selected from LiYF4, NaY, NaYF4, NaGdF4, and CaF3, at least one sensitizer selected from Sm3+, Nd3+, Dy3+, Ho3+, and Yb3+ doped in the at least one host, and at least one activator selected from Er3+, Ho3+, Tm3+, and Eu3+ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.

公开(公告)号：US20240239675A1

公开(公告)日：2024-07-18

申请号：US18023553

申请日：2021-08-24

Applicant: RESEARCH INSTITUTE OF INDUSTRIAL SCIENCE & SCIENCE & TECHNOLOGY ,  POSCO CO., LTD.

Inventor： Woo Chul JUNG ,  Gi-Chun HAN ,  Young-Seon KO ,  Seung Goo KIM ,  Kiyoung KIM ,  Woonkyoung PARK ,  Kyunghoon KIM ,  Juyoung KIM ,  Hyun Woo LEE

IPC: C01D15/02

CPC classification number: C01D15/02

Abstract: The present disclosure relates to a lithium hydroxide manufacturing method, which includes: roasting a lithium-containing raw material in sulfuric acid; leaching the roasted lithium-containing raw material to obtain a solution containing lithium sulfate; a first purifying the leaching solution with a pH of 7.1 to 9.5; a second purifying the first purified solution with pH of 9 to 11; and obtaining an aqueous solution of a lithium hydroxide by bipolar electrodialysis of the second purified a solution.