公开(公告)号：US10906888B2

公开(公告)日：2021-02-02

申请号：US16316688

申请日：2017-07-07

申请人： Pfizer Inc.

发明人： Agustin Casimiro-Garcia ,  Joseph Walter Strohbach ,  David Hepworth ,  Frank Eldridge Lovering ,  Chulho Choi ,  Christophe Philippe Allais ,  Stephen Wayne Wright

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D471/08 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/10 ,  C07D498/18

摘要： Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：US20190315715A1

公开(公告)日：2019-10-17

申请号：US16316688

申请日：2017-07-07

申请人： Pfizer Inc.

发明人： Agustin Casimiro-Garcia ,  Joseph Walter Strohbach ,  David Hepworth ,  Frank Eldridge Lovering ,  Chulho Choi ,  Christophe Philippe Allais ,  Stephen Wayne Wright

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D471/08 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D498/10 ,  C07D498/18

摘要： Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：US10316018B2

公开(公告)日：2019-06-11

申请号：US16206166

申请日：2018-11-30

申请人： PFIZER INC.

发明人： Katherine Lin Lee ,  Christophe Philippe Allais ,  Christoph Martin Dehnhardt ,  Lori Krim Gavrin ,  Seungil Han ,  David Hepworth ,  Arthur Lee ,  Frank Eldridge Lovering ,  John Paul Mathias ,  Dafydd Rhys Owen ,  Nikolaos Papaioannou ,  Eddine Saiah ,  Joseph Walter Strohbach ,  John David Trzupek ,  Stephen Wayne Wright ,  Christoph Wolfgang Zapf

IPC分类号： A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K31/4015 ,  A61K45/06 ,  C07D401/12 ,  C07D413/04 ,  C07D207/273 ,  C07D491/18 ,  C07D471/04 ,  C07D413/14 ,  C07D401/14

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：US10174000B2

公开(公告)日：2019-01-08

申请号：US15754650

申请日：2016-08-16

申请人： PFIZER INC.

发明人： Katherine Lin Lee ,  Christophe Philippe Allais ,  Christoph Martin Dehnhardt ,  Lori Krim Gavrin ,  Seungil Han ,  David Hepworth ,  Arthur Lee ,  Frank Eldridge Lovering ,  John Paul Mathias ,  Dafydd Rhys Owen ,  Nikolaos Papaioannou ,  Eddine Saiah ,  Joseph Walter Strohbach ,  John David Trzupek ,  Stephen Wayne Wright ,  Christoph Wolfgang Zapf

IPC分类号： C07D207/273 ,  C07D401/12 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D491/18 ,  A61K31/4015 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K45/06

摘要： Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.