公开(公告)号：US20240108674A1

公开(公告)日：2024-04-04

申请号：US18276232

申请日：2022-02-08

Applicant: PANJAB UNIVERSITY, CHANDIGARH

Inventor： Maninder KARAN ,  Karan VASISHT ,  Neetika SHARMA ,  Indu Pal KAUR ,  Vikas GAUTAM ,  Simarjot Kaur SANDHU ,  Jasmine KAUR

IPC: A61K36/29 ,  A61K9/51

CPC classification number: A61K36/29 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5161 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/51

Abstract: The present invention relates to a process for extraction and freeze-drying of a Berberis extract. More particularly, the invention provides an optimized process for freeze-drying/lyophilization to increase the solubility of the extract into the surfactants for enhanced incorporation into a nano-carrier system. Furthermore, the present invention also relates to a lipid nano-formulation of freeze-dried Berberis extract and process for preparing the same by high-pressure homogenization. The invention also relates to the lipid nano-formulation of freeze-dried Berberis extract for efficient drug delivery, for dermatological and cosmeceutical purposes, for treating diabetes and diabetes associated complications, as a wound healer, as an antimicrobial, as an anti-infective, as an anti-inflammatory agent and as an antioxidant.

公开(公告)号：US20240115512A1

公开(公告)日：2024-04-11

申请号：US18276227

申请日：2022-02-08

Applicant: PANJAB UNIVERSITY, CHANDIGARH

Inventor： Karan VASISHT ,  Maninder KARAN ,  Neetika SHARMA ,  Indu Pal KAUR ,  Vikas GAUTAM ,  Simarjot Kaur SANDHU

IPC: A61K9/51 ,  A61K31/473 ,  A61P31/04

CPC classification number: A61K9/5123 ,  A61K31/473 ,  A61P31/04 ,  A61K2800/41

Abstract: The present invention relates to a simple and convenient process for preparing solid lipid sustained release nanoparticles for berbamine delivery. The process involves preparation of nanoparticles by maintaining the pH of the aqueous or lipid phase so that high drug loading of 12-50% w/w with respect to the lipid matrix and high entrapment efficiency of more than 90% for berbamine in the solid lipid nanoparticles is achieved. The nanoformulation obtained by the process of the present invention has increased efficacy and exhibited any therapeutic property identical to free berbamine such as antiviral-cum-antibacterial agent for the treatment of microbial infections especially resistant Acinetobacter infections in treating diabetes and more specifically diabetes associated complications. Use may be extended to other diseases like COVID 19.