公开(公告)号：US20210205237A1

公开(公告)日：2021-07-08

申请号：US17202951

申请日：2021-03-16

申请人： Pacific University

发明人： John P. Harrelson ,  Deepa A. Rao

IPC分类号： A61K31/11 ,  A61P25/34 ,  A61K9/00 ,  A61K31/465

摘要： Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.

公开(公告)号：US20240115518A1

公开(公告)日：2024-04-11

申请号：US18520444

申请日：2023-11-27

申请人： PACIFIC UNIVERSITY

发明人： John P. Harrelson ,  Deepa A. Rao

IPC分类号： A61K31/11 ,  A61K9/00 ,  A61K31/465 ,  A61P25/34

CPC分类号： A61K31/11 ,  A61K9/0053 ,  A61K31/465 ,  A61P25/34

摘要： Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.

公开(公告)号：US20240325317A1

公开(公告)日：2024-10-03

申请号：US18737889

申请日：2024-06-07

申请人： PACIFIC UNIVERSITY

发明人： John P. Harrelson ,  Deepa A. Rao

IPC分类号： A61K31/11 ,  A61K9/00 ,  A61K31/465 ,  A61P25/34

CPC分类号： A61K31/11 ,  A61K9/0053 ,  A61K31/465 ,  A61P25/34

摘要： Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde ((2E)-3-Phenylprop-2-enal):




Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.

公开(公告)号：US11865086B2

公开(公告)日：2024-01-09

申请号：US17649328

申请日：2022-01-28

申请人： Pacific University

发明人： John P. Harrelson ,  Deepa A. Rao

IPC分类号： A61K31/11 ,  A61P25/34 ,  A61K9/00 ,  A61K31/465

CPC分类号： A61K31/11 ,  A61K9/0053 ,  A61K31/465 ,  A61P25/34

摘要： Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.

公开(公告)号：US20220142946A1

公开(公告)日：2022-05-12

申请号：US17649328

申请日：2022-01-28

申请人： Pacific University.

发明人： John P. Harrelson ,  Deepa A. Rao

IPC分类号： A61K31/11 ,  A61P25/34 ,  A61K9/00 ,  A61K31/465

摘要： Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde. Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.

公开(公告)号：US11266610B2

公开(公告)日：2022-03-08

申请号：US16663291

申请日：2019-10-24

申请人： PACIFIC UNIVERSITY

发明人： John P. Harrelson ,  Deepa A. Rao

IPC分类号： A61K31/11 ,  A61P25/34 ,  A61K9/00 ,  A61K31/465

摘要： Compounds, compositions, and methods of use of such compounds and compositions are provided for reducing human dependency to nicotine. In one example, a method of treating an individual with an addiction to nicotine comprises administering to the individual a compound that is a structural analog of trans-cinnamaldehyde ((2E)-3-Phenylprop-2-enal): Based on the administration, a rate at which nicotine is metabolized may be reduced, which in turn may reduce a desire for the individual to consume nicotine-containing products.