公开(公告)号：US20190175746A1

公开(公告)日：2019-06-13

申请号：US16323727

申请日：2017-08-04

Applicant: Ossianix, Inc.

Inventor： Pawel STOCKI ,  Krzysztof Bartlomiej WICHER ,  Julia Lynn RUTKOWSKI ,  Fabrizio COMPER ,  Mykhaylo DEMYDCHUK ,  Jaroslaw Michal SZARY

IPC: A61K47/64 ,  C12N15/113 ,  A61K47/56

Abstract: The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to the methods used to identify membrane receptors or transporters capable of carrying cargo specifically targeted to the parenchymal tissue of the brain and to in vivo enrichment methods for selecting peptides that are transported across the blood-brain barrier (“BBB”), or analogously, across other membrane containing organs or structures, such as liver, spleen, kidney and tumors.

公开(公告)号：US20240050581A1

公开(公告)日：2024-02-15

申请号：US18448332

申请日：2023-08-11

Applicant: Ossianix, Inc.

Inventor： Pawel STOCKI ,  Krzysztof Bartlomiej WICHER ,  Julia Lynn RUTKOWSKI ,  Fabrizio COMPER ,  Mykhaylo DEMYDCHUK ,  Jaroslaw Michal SZARY

IPC: A61K47/64 ,  G01N33/68 ,  C07K16/28 ,  C07K16/40 ,  C12N15/10 ,  C12N15/09 ,  G01N33/58 ,  A61K47/56 ,  C12N15/113

CPC classification number: A61K47/64 ,  G01N33/68 ,  C07K16/2887 ,  C07K16/40 ,  C12N15/1037 ,  C07K16/2881 ,  C12N15/09 ,  G01N33/58 ,  A61K47/56 ,  C12N15/113 ,  C07K2317/94 ,  C07K2317/734 ,  A61K2039/505

Abstract: The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to the methods used to identify membrane receptors or transporters capable of carrying cargo specifically targeted to the parenchymal tissue of the brain and to in vivo enrichment methods for selecting peptides that are transported across the blood-brain barrier (“BBB”), or analogously, across other membrane containing organs or structures, such as liver, spleen, kidney and tumors.

公开(公告)号：US20220031857A1

公开(公告)日：2022-02-03

申请号：US17381775

申请日：2021-07-21

Applicant: Ossianix, Inc.

Inventor： Pawel STOCKI ,  Krzysztof Bartlomiej WICHER ,  Julia Lynn RUTKOWSKI ,  Fabrizio COMPER ,  Mykhaylo DEMYDCHUK ,  Jaroslaw Michal SZARY

IPC: A61K47/64 ,  G01N33/68 ,  C07K16/28 ,  C07K16/40 ,  C12N15/10 ,  C12N15/09 ,  G01N33/58 ,  A61K47/56 ,  C12N15/113

Abstract: The present invention relates to the fields of molecular medicine and targeted delivery of therapeutic or diagnostic agents to cells outside the vascular system and into the parenchymal tissue of organs within the body. More specifically, the present invention relates to the methods used to identify membrane receptors or transporters capable of carrying cargo specifically targeted to the parenchymal tissue of the brain and to in vivo enrichment methods for selecting peptides that are transported across the blood-brain barrier (“BBB”), or analogously, across other membrane containing organs or structures, such as liver, spleen, kidney and tumors.