公开(公告)号：US20230373985A1

公开(公告)日：2023-11-23

申请号：US18030723

申请日：2021-07-12

申请人： Origenis Gmbh ,  Neuron23, Inc.

发明人： Roland KOESTLER ,  Nasser Yehia ,  Jean Tassel ,  Marcus Wegmann ,  Federico Medda ,  Patricia Perez-Gallan ,  Christiane Gilch ,  Michael Thormann ,  Andreas Treml ,  Michael Almstetter ,  Zhonghua Pei ,  Scott Savage

IPC分类号： C07D417/12 ,  C07D401/14 ,  C07D491/052 ,  C07D487/04 ,  C07D413/12 ,  C07D249/06 ,  C07D401/12 ,  C07D413/14 ,  C07D417/14 ,  C07D405/12 ,  C07D231/38 ,  C07D498/04

CPC分类号： C07D417/12 ,  C07D401/14 ,  C07D491/052 ,  C07D487/04 ,  C07D413/12 ,  C07D249/06 ,  C07D401/12 ,  C07D413/14 ,  C07D417/14 ,  C07D405/12 ,  C07D231/38 ,  C07D498/04

摘要： The present invention relates to novel compounds that modulate the activity of one or more kinases, such as TYK2 or mutants thereof. The compounds, which may be kinase inhibitors or activators, are useful for treating autoimmune diseases, such as, such as psoriasis, lupus, multiple sclerosis, and inflammatory bowel disease.

公开(公告)号：US20240208972A1

公开(公告)日：2024-06-27

申请号：US18512306

申请日：2023-11-17

申请人： NEURON23, INC.

发明人： Ming Yu ,  Gyanendra Kumar ,  Zhonghua Pei ,  Scott Savage ,  Kejia Wu ,  Jim X. Zheng

IPC分类号： C07D471/14 ,  C07D471/22 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D471/14 ,  C07D471/22 ,  C07D487/04 ,  C07D519/00

摘要： The invention provides compounds that modulate the activity of protein kinases that are associated with human diseases, disorders, and conditions. In particular, compounds of the invention inhibit LRRK2.