公开(公告)号：US20240000928A1

公开(公告)日：2024-01-04

申请号：US18069489

申请日：2022-12-21

Applicant: OnkosXcel Therapeutics, LLC

Inventor： Luca RASTELLI ,  Aparna Katoch SAPRA ,  Vimal MEHTA

IPC: A61K39/395 ,  A61K38/04 ,  C12N15/113 ,  A61K45/06 ,  A61K31/69 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K38/04 ,  C12N15/1137 ,  A61K45/06 ,  A61K39/39541 ,  A61K31/69 ,  C07K16/2818 ,  A61K2039/505

Abstract: The present invention discloses a method of treating, preventing or ameliorating tumor growth by administering a therapeutic agent that selectively inhibits dipeptidyl peptidase including fibroblast activation protein and dipeptidyl peptidase 8/9 in combination with an immune checkpoint inhibitor. The method specifically discloses use of Talabostat in combination with an immune checkpoint inhibitor, its pharmaceutical composition and process of preparing such composition.