公开(公告)号：US09920045B2

公开(公告)日：2018-03-20

申请号：US15344372

申请日：2016-11-04

Applicant: Omeros Corporation

Inventor： Ekaterina Albert ,  Jennifer Leigh Nelson ,  Christopher Scott Seadeek ,  Karl Reineke ,  Marco Jonas ,  Suba Iyer ,  Xufeng Sun ,  Neil S. Cutshall ,  Jennifer Lynn Gage ,  Thomas L. Little ,  Wayne Douglas Luke ,  Elisabeth C. A. Brot ,  Michael James McDermott

IPC: C07D417/10

CPC classification number: C07D417/10 ,  C07B2200/13

Abstract: The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.

公开(公告)号：US20180057484A1

公开(公告)日：2018-03-01

申请号：US15482604

申请日：2017-04-07

Applicant: Omeros Corporation

Inventor： Neil S. Cutshall ,  Jennifer Lynn Gage ,  Thomas L. Little ,  Wayne Douglas Luke ,  Elisabeth C. A. Brot ,  Marco Jonas ,  Michael James McDermott ,  Karl E. Reineke

IPC: C07D417/10 ,  C07D285/12 ,  C07F3/02 ,  C07D413/10

CPC classification number: C07D417/10 ,  C07D285/12 ,  C07D413/10 ,  C07F3/02

Abstract: The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, which is useful in the inhibition of PDE10.

公开(公告)号：US20170166559A1

公开(公告)日：2017-06-15

申请号：US15344372

申请日：2016-11-04

Applicant: Omeros Corporation

Inventor： Ekaterina Albert ,  Jennifer Leigh Nelson ,  Christopher Scott Seadeek ,  Karl Reineke ,  Marco Jonas ,  Suba Iyer ,  Xufeng Sun ,  Neil S. Cutshall ,  Jennifer Lynn Gage ,  Thomas L. Little ,  Wayne Douglas Luke ,  Elisabeth C. A. Brot ,  Michael James McDermott

IPC: C07D417/10

CPC classification number: C07D417/10 ,  C07B2200/13

Abstract: The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.

公开(公告)号：US09650368B2

公开(公告)日：2017-05-16

申请号：US14696287

申请日：2015-04-24

Applicant: Omeros Corporation

Inventor： Neil S. Cutshall ,  Jennifer Lynn Gage ,  Thomas L. Little ,  Wayne Douglas Luke ,  Elisabeth C. A. Brot ,  Marco Jonas ,  Michael James McDermott ,  Karl E. Reineke

IPC: C07D417/10 ,  C07D413/10 ,  C07F3/02 ,  C07D285/12

CPC classification number: C07D417/10 ,  C07D285/12 ,  C07D413/10 ,  C07F3/02

Abstract: The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, which is useful in the inhibition of PDE10.