公开(公告)号：US20220194942A1

公开(公告)日：2022-06-23

申请号：US17679075

申请日：2022-02-23

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： Hiroyuki Kouji ,  Kentaro Yamada ,  Akira Katoh ,  Toshimasa Ishizaki ,  Shigeru Matsuoka ,  Akira Nishizono ,  Tadashi Mishina ,  Atsushi Yoshimori

IPC分类号： C07D471/18 ,  A61P31/14 ,  A61P35/00 ,  C07D471/08

摘要： The present disclosure provides a compound that is useful for the treatment and prophylaxis of rabies. The present disclosure provides a compound represented by formula XXIIF or formula XXIIB: wherein R1, R2A, R2B, R3, and R4 are defined in the specification, a solvent, or a pharmaceutically acceptable salt thereof, use of such a compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prophylaxis of rabies and cancer, a pharmaceutical composition comprising such a compound, solvate, or pharmaceutically acceptable salt thereof, and a method for the treatment or prophylaxis of rabies and cancer using the same.

公开(公告)号：US11292794B2

公开(公告)日：2022-04-05

申请号：US16791715

申请日：2020-02-14

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： Hiroyuki Kouji ,  Kentaro Yamada ,  Akira Katoh ,  Toshimasa Ishizaki ,  Shigeru Matsuoka ,  Akira Nishizono ,  Tadashi Mishina ,  Atsushi Yoshimori

IPC分类号： C07D471/08 ,  C07D471/18 ,  A61P31/14 ,  A61P35/00

摘要： The present disclosure provides a compound that is useful for the treatment and prophylaxis of rabies. The present disclosure provides a compound represented by formula XXIF or formula XXIB: wherein R1, R2A, R2B, R3, and R4 are defined in the specification, a solvent, or a pharmaceutically acceptable salt thereof, use of such a compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prophylaxis of rabies and cancer, a pharmaceutical composition comprising such a compound, solvate, or pharmaceutically acceptable salt thereof, and a method for the treatment or prophylaxis of rabies and cancer using the same.