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公开(公告)号：US11938105B1
公开(公告)日：2024-03-26
申请号：US18067924
申请日：2022-12-19
IPC分类号： A61K31/167 , A61K45/06 , A61P21/06
CPC分类号： A61K31/167 , A61K45/06 , A61P21/06
摘要： In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
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公开(公告)号：US20240285556A1
公开(公告)日：2024-08-29
申请号：US18615242
申请日：2024-03-25
IPC分类号： A61K31/167 , A61K45/06 , A61P21/06
CPC分类号： A61K31/167 , A61K45/06 , A61P21/06
摘要： In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
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公开(公告)号：US20150150832A1
公开(公告)日：2015-06-04
申请号：US14547771
申请日：2014-11-19
发明人： Ching-Shih Chen , Tanios Bekaii-Saab , Denis Guttridge , Guido Marcucci , Samuel Kulp , Yu-Chou Tseng
IPC分类号： A61K31/16
CPC分类号： A61K31/16 , A61K31/166 , A61K31/167
摘要： Methods of suppressing cachexia in a mammal with cancer comprising administering HDAC inhibitors are provided. Aspects include methods of administering an HDAC class 1 and 2b inhibitor in an amount effective to substantially maintain the mammal's weight compared to a mammal that does receive the HDAC class 1 and 2b inhibitor.
摘要翻译： 提供了抑制具有癌症的哺乳动物的恶病质的方法，包括施用HDAC抑制剂。 方面包括与确实接受HDAC class 1和2b抑制剂的哺乳动物相比，以有效基本上维持哺乳动物体重的量施用HDAC 1类和2b类抑制剂的方法。
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公开(公告)号：US20200289438A1
公开(公告)日：2020-09-17
申请号：US16646424
申请日：2018-09-13
IPC分类号： A61K31/167 , A61K45/06 , A61P21/06
摘要： In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
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公开(公告)号：US11529323B2
公开(公告)日：2022-12-20
申请号：US16646424
申请日：2018-09-13
IPC分类号： A61K31/167 , A61P21/06 , A61K45/06
摘要： In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.
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公开(公告)号：US11219607B2
公开(公告)日：2022-01-11
申请号：US14547771
申请日：2014-11-19
发明人： Ching-Shih Chen , Tanios Bekaii-Saab , Denis Guttridge , Guido Marcucci , Samuel Kulp , Yu-Chou Tseng
IPC分类号： A61K31/16 , A61K31/166 , A61K31/167
摘要： Methods of suppressing cachexia in a mammal with cancer comprising administering HDAC inhibitors are provided. Aspects include methods of administering an HDAC class 1 and 2b inhibitor in an amount effective to substantially maintain the mammal's weight compared to a mammal that does receive the HDAC class 1 and 2b inhibitor.
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