公开(公告)号：US20240417738A1

公开(公告)日：2024-12-19

申请号：US18703637

申请日：2022-10-24

Applicant: Ohio State Innovation Foundation

Inventor： Chun-Tien KUO ,  Zhongkun ZHANG ,  Robert LEE

IPC: C12N15/113 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/01 ,  A61K31/4745 ,  A61K31/7084 ,  A61K31/711 ,  A61P35/00

Abstract: Disclosed are compositions and methods for the treatment of cancer. For example, provided herein are pharmaceutical composition comprising a lipid particle encapsulating a first TLR agonist and a second TLR agonist, as well as methods of using thereof to treat or prevent cancer. Also provided herein are pharmaceutical compositions comprising a lipid particle encapsulating a TLR agonist and an antisense oligonucleotide capable of reducing expression of PD-L1 in a target cell, as well as methods of using thereof to treat or prevent cancer.

公开(公告)号：US20240398786A1

公开(公告)日：2024-12-05

申请号：US18580878

申请日：2022-07-20

Applicant: Ohio State Innovation Foundation

Inventor： Terence WILLIAMS ,  Robert LEE

IPC: A61K31/4745 ,  A61K47/64 ,  A61P35/00

Abstract: The present disclosure provides albumin conjugates for the treatment of cancer, and more particularly conjugates of albumin with 7-ethyl-10-hydroxy-camptothecin.

公开(公告)号：US20240173374A1

公开(公告)日：2024-05-30

申请号：US18279004

申请日：2022-02-25

Applicant: Ohio State Innovation Foundation

Inventor： Robert LEE

IPC: A61K38/05 ,  A61K9/127 ,  A61P35/00

CPC classification number: A61K38/05 ,  A61K9/1271 ,  A61P35/00

Abstract: Described are liposomal formulation for the improved delivery of boronic acid esters of boronic acid therapeutic agents. The liposomal formulation can include (i) liposomes formed from a vesicle-forming lipid; and (ii) a capturing agent-active agent complex encapsulated in the liposomes.

公开(公告)号：US20190256848A1

公开(公告)日：2019-08-22

申请号：US16347311

申请日：2017-11-03

Applicant: Ohio State Innovation Foundation ,  Aalborg University

Inventor： Ramiro GARZON ,  Adrienne DORRANCE ,  Dimitrios PAPAIOANNOU ,  Robert LEE ,  Sakari KAUPPINEN ,  Andreas PETRI ,  Charlotte ALBÆK THRUE

IPC: C12N15/113

Abstract: The present disclosure relates to antisense oligomers targeting the long non-coding RNA HOXB-AS3 and methods of treating acute myeloid leukemia.