公开(公告)号：US20200277318A1

公开(公告)日：2020-09-03

申请号：US16878109

申请日：2020-05-19

Applicant: OTSUKA CHEMICAL CO., LTD.

Inventor： Hiroaki YUASA ,  Hiroki OKAZAKI

IPC: C07F9/6571 ,  A61P19/00 ,  A61P29/00 ,  A61P35/00 ,  C07F9/6574

Abstract: An object of the present invention is to provide crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and a method for producing the crystal. The present invention provides a crystal of a cyclic phosphonic acid sodium salt (2ccPA) represented by formula (1):

公开(公告)号：US20220396594A1

公开(公告)日：2022-12-15

申请号：US17787522

申请日：2020-12-23

Applicant: OTSUKA CHEMICAL CO., LTD.

Inventor： Shin YONEYAMA ,  Hiroki OKAZAKI

IPC: C07F9/6574

Abstract: Provided is a degradation inhibitor that delays the progress of the degradation reaction of 2ccPA and has an excellent stabilization effect by using a carbacyclic phosphatidic acid compound represented by formula (1): wherein R1 represents hydrogen, alkali metal, alkyl, arylalkyl, or aryl; bonds indicated by solid and dotted lines represent single or double bonds; wavy lines represent single bonds; and when the single bond is adjacent to a double bond, the steric configuration is E-configuration, Z-configuration, or any mixture thereof.

公开(公告)号：US20170233421A1

公开(公告)日：2017-08-17

申请号：US15501525

申请日：2015-08-12

Applicant: OTSUKA CHEMICAL CO., LTD.

Inventor： Hiroaki YUASA ,  Hiroki OKAZAKI

IPC: C07F9/6571

CPC classification number: C07F9/657163 ,  A61K31/665 ,  A61P19/00 ,  A61P29/00 ,  A61P35/00 ,  C07B2200/13 ,  C07F9/657181 ,  C07F9/65742

Abstract: An object of the present invention is to provide a crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and a method for producing the crystal. The present invention provides a crystal of a cyclic phosphonic acid sodium salt (2ccPA) represented by formula (1):

公开(公告)号：US20200277317A1

公开(公告)日：2020-09-03

申请号：US16877915

申请日：2020-05-19

Applicant: OTSUKA CHEMICAL CO., LTD.

Inventor： Hiroaki YUASA ,  Hiroki OKAZAKI

IPC: C07F9/6571 ,  A61P19/00 ,  A61P29/00 ,  A61P35/00 ,  C07F9/6574

Abstract: An object t of the present invention is to provide crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and a method for producing the crystal. The present invention provides a crystal of a cyclic phosphonic acid sodium salt (2ccPA) represented by formula (1):

公开(公告)号：US20190330251A1

公开(公告)日：2019-10-31

申请号：US16460332

申请日：2019-07-02

Applicant: OTSUKA CHEMICAL CO., LTD.

Inventor： Hiroaki YUASA ,  Hiroki OKAZAKI

IPC: C07F9/6571 ,  A61P35/00 ,  A61P29/00 ,  A61P19/00 ,  C07F9/6574

Abstract: An object t of the present invention is to proroaide crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and a method for producing the crystal. The present invention provides a crystal of a cyclic phosphonic acid sodium salt (2ccPA) represented by formula (1):