公开(公告)号：US12049445B2

公开(公告)日：2024-07-30

申请号：US17521004

申请日：2021-11-08

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Toshihide Watanabe ,  Kensuke Kusumi ,  Satomi Imaide ,  Toshimitsu Endo ,  Takaki Komiya ,  Naomi Tsuburaya

IPC: C07D205/04 ,  C07C49/252 ,  C07C49/577

CPC classification number: C07D205/04 ,  C07C49/252 ,  C07C49/577

Abstract: A compound represented by the general formula (V)




wherein all the symbols are as defined in the specification, has an improved balance of the agonist activity against the S1P5 receptor relative to the S1P1 receptor, and can thus serve as a therapeutic agent for S1P5-mediated diseases such as schizophrenia and Binswanger's disease and other neurodegenerative diseases.

公开(公告)号：US11198672B2

公开(公告)日：2021-12-14

申请号：US16970865

申请日：2019-02-21

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Toshihide Watanabe ,  Kensuke Kusumi ,  Satomi Imaide ,  Toshimitsu Endo ,  Takaki Komiya ,  Naomi Tsuburaya

IPC: C07D205/04 ,  C07C49/252 ,  C07C49/577

Abstract: A compound represented by the general formula (V) wherein all the symbols are as defined in the specification, has an improved balance of the agonist activity against the S1P5 receptor relative to the S1P1 receptor, and can thus serve as a therapeutic agent for S1P5-mediated diseases such as schizophrenia and Binswanger's disease and other neurodegenerative diseases.