公开(公告)号：US20250051344A1

公开(公告)日：2025-02-13

申请号：US18737832

申请日：2024-06-07

Applicant: Nurix Therapeutics, Inc.

Inventor： Katherine Keenan ,  Rishab N. Iyer ,  Tim R. Kane ,  Jake C. Swartzel

IPC: C07D487/10 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5386 ,  A61K31/551 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/10 ,  C07D519/00

Abstract: The present disclosure provides bifunctional compounds as selective SMARCA2 degraders via ubiquitin proteosome pathway, and their therapeutic use for treating cancers.