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![AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS](/abs-image/US/2022/08/18/US20220257551A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220257551A1
公开(公告)日：2022-08-18
申请号：US17738565
申请日：2022-05-06
发明人： Lili FENG , Sven Erik GODTFREDSEN , Paul Allen SUTTON , Mahavir PRASHAD , Michael J. GIRGIS , Bin HU , Yugang LIU , Thomas J. BLACKLOCK , Piotr Henryk KARPINSKI
IPC分类号： A61K31/216 , A61K31/41 , A61K45/06 , A61K31/4422 , A61K31/5415 , C07C233/47 , C07D257/04 , C07D207/50
摘要： An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.
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![COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND CATIONS](/abs-image/US/2021/11/25/US20210361610A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210361610A1
公开(公告)日：2021-11-25
申请号：US17395305
申请日：2021-08-05
发明人： Lili FENG , Sven Erik GODTFREDSEN , Paul Allen SUTTON , Mahavir PRASHAD , Michael J. GIRGIS , Bin HU , Yugang LIU , Thomas J. BLACKLOCK , Piotr Henryk KARPINSKI
IPC分类号： A61K31/216 , A61K31/41 , A61K45/06 , A61K31/4422 , A61K31/5415 , C07C233/47 , C07D257/04 , C07D207/50
摘要： A compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and one or more monovalent cations such as Na+ useful for the treatment of hypertension and/or heart failure.
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![AMORPHOUS SOLID FORM OF COMPOUNDS CONTAINING S-N-VALERYL-N-{[2'-(1H-TETRAZOLE-5-YL)-BIPHENYL-4-YL]-METHYL}-VALINE AND (2R,4S)-5-BIPHENYL-4-YL-4-(3-CARBOXY-PROPIONYLAMINO)-2-METHYL-PENTANOIC ACID ETHYL ESTER MOIETIES AND SODIUM CATIONS](/abs-image/US/2022/10/20/US20220331282A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220331282A1
公开(公告)日：2022-10-20
申请号：US17847588
申请日：2022-06-23
发明人： Lili FENG , Sven Erik GODTFREDSEN , Paul Allen SUTTON , Mahavir PRASHAD , Michael J. GIRGIS , Bin HU , Yugang LIU , Thomas J. BLACKLOCK , Piotr Henryk KARPINSKI
IPC分类号： A61K31/216 , A61K31/41 , A61K45/06 , A61K31/4422 , A61K31/5415 , C07C233/47 , C07D257/04 , C07D207/50
摘要： An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.
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