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公开(公告)号：US20240269304A1
公开(公告)日：2024-08-15
申请号：US18038435
申请日：2021-11-23
发明人： Matthew T. Burger , Zhuoliang Chen , Joseph Anthony D'Alessio , Eric McNeill , Katsumasa Nakajima , Richard Vaughan Newcombe , Mark G. Palermo , Bing Yu , Qiang Zhang , Frédéric Colland , James Edward Paul Davidson , Lea Delacour , Patrice Desos , Olivier Geneste , Vesela Kostova , Andras Kotschy , Ana Leticia Maragno , James Brooke Murray , Tibor Novak , Jérôme Benoit Starck
CPC分类号： A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6889 , A61P35/00
摘要： Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise a Bcl-xL inhibitor drug moiety. The disclosure farther relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising Bcl-xL inhibitor drug moiety and methods of making same are also disclosed.
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公开(公告)号：US11332472B2
公开(公告)日：2022-05-17
申请号：US16764982
申请日：2018-11-28
发明人： András Kotschy , Csaba Wéber , Attila Vasas , Árpád Kiss , Balázs Molnár , Ágnes Strofek , Vilibald Kun , James Brooke Murray , Alba Macias , Elodie Lewkowicz , Maïa Chanrion , Lisa Ivanschitz , Olivier Geneste
IPC分类号： A61K31/4523 , C07D211/48 , C07D487/04 , A61K45/06
摘要： Compounds of formula (I): wherein R1, R2, R3, B, W, Z, m and n are as defined in the description.
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3.发明授权公开(公告)号：US10688101B2
公开(公告)日：2020-06-23
申请号：US16271171
申请日：2019-02-08
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US09603854B2
公开(公告)日：2017-03-28
申请号：US14799840
申请日：2015-07-15
发明人： Thierry Le Diguarher , Patrick Casara , Jérôme-Benoît Starck , Jean-Michel Henlin , James Edward Paul Davidson , James Brooke Murray , Christopher John Graham , I-Jen Chen , Olivier Geneste , John Hickman , Stéphane Depil , Arnaud Le Tiran , Miklos Nyerges , Guillaume De Nanteuil
IPC分类号： C07D471/04 , A61K31/4725 , C07D487/04 , C07D491/052 , A61K31/553 , A61N5/10 , C07D471/00 , C07D207/30 , C07D211/06 , C07D211/80 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K45/06 , C07D498/04
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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5.发明授权Phosphate compounds, a process for their preparation and pharmaceutical compositions containing them 有权磷酸盐化合物，其制备方法和含有它们的药物组合物公开(公告)号：US09115159B2
公开(公告)日：2015-08-25
申请号：US14337577
申请日：2014-07-22
发明人： Arnaud Le Tiran , Thierry Le Diguarher , Jérôme-Benoit Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen
IPC分类号： A61K31/675 , C07F9/6561 , C07F9/09 , A61K45/06 , A61N5/10 , C07F9/6558
CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561
摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中X，Y，A1，A2，Ra，Rb，Rc，Rd，R3，R4，T和R5如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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公开(公告)号：US20150051189A1
公开(公告)日：2015-02-19
申请号：US14374071
申请日：2013-01-23
发明人： Thierry Le Diguarher , Patrick Casara , Jérôme-Benoît Starck , Jean-Michel Henlin , James Edward Paul Davidson , James Brooke Murray , Christopher John Graham , I-Jen Chen , Olivier Geneste , John Hickman , Stéphane Depil , Arnaud Le Tiran , Miklos Nyerges , Guillaume De Nanteuil
IPC分类号： C07D471/04 , A61K45/06 , A61K31/496 , A61K31/553 , A61N5/10 , C07D498/04 , A61K31/5383 , A61K31/55 , A61K31/541 , A61K31/475 , A61K31/5377 , C07D487/04
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US10689364B2
公开(公告)日：2020-06-23
申请号：US15704330
申请日：2017-09-14
发明人： James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Claire Walmsley , Mark Dodsworth , Johannes W. G. Meissner , Paul Brough , Imre Fejes , János Tatai , Miklós Nyerges , András Kotschy , Zoltán Szlávik , Olivier Geneste , Arnaud Le Tiran , Thierry Le Diguarher , Jean-Michel Henlin , Jérôme-Benoît Starck , Anne-Françoise Guillouzic , Guillaume De Nanteuil
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4725 , C07D409/14 , C07D471/04 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/675 , A61K45/06 , A61N5/10 , C07D417/14 , C07F9/6561
摘要： Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p′, q, and q′ are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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8.发明申请公开(公告)号：US20190248805A1
公开(公告)日：2019-08-15
申请号：US16394308
申请日：2019-04-25
发明人： Balázs Bálint , Márton Csékei , Zoltán Szabó , Zoltán Szlávik , András Kotschy , Maïa Chanrion , Olivier Geneste , I-Jen Chen , James Edward Paul Davidson , James Brooke Murray , Szabolcs Sipos , Levente Ondi , Ágnes Proszenyák
IPC分类号： C07D495/04 , C07D491/048 , C07D491/04 , C07D333/56 , A61P35/02 , C07D307/81 , C07D307/80 , C07D209/12 , C07D403/12 , C07D487/04 , C07D471/04 , C07D409/12 , C07D405/12 , C07D405/04
CPC分类号： C07D495/04 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D209/12 , C07D307/80 , C07D307/81 , C07D333/56 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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公开(公告)号：US10258626B2
公开(公告)日：2019-04-16
申请号：US15428493
申请日：2017-02-09
发明人： Thierry Le Diguarher , Patrick Casara , Jérôme-Benoît Starck , Jean-Michel Henlin , James Edward Paul Davidson , James Brooke Murray , Christopher John Graham , I-Jen Chen , Olivier Geneste , John Hickman , Stéphane Depil , Arnaud Le Tiran , Mikl{dot over (o)}s Nyerges , Guillaume De Nanteuil
IPC分类号： A61K31/55 , A61K31/475 , A61K31/496 , A61K31/541 , A61K31/553 , A61K31/4725 , A61K31/5377 , A61K31/5383 , C07D491/052 , C07D401/02 , C07D401/12 , A61N5/10 , C07D471/00 , C07D471/04 , C07D487/04 , C07D207/30 , C07D211/06 , C07D211/80 , A61K45/06 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：US09670227B2
公开(公告)日：2017-06-06
申请号：US14576683
申请日：2014-12-19
发明人： András Kotschy , Zoltán Szlávik , Márton Csékei , Attila Paczal , Zoltán Szabó , Szabolcs Sipos , Gábor Radics , Ágnes Proszenyák , Balázs Bálint , Alain Bruno , Olivier Geneste , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Françoise Perron-Sierra
IPC分类号： C07D239/00 , C07D333/00 , C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K45/06 , A61N5/10
CPC分类号： A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K45/06 , A61N5/10 , C07D495/04
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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