公开(公告)号：US10259827B2

公开(公告)日：2019-04-16

申请号：US15807462

申请日：2017-11-08

申请人： NOVARTIS AG

发明人： Jian Ding ,  Marie-Helene Larraufie ,  Deborah Rothman ,  Nik Savage ,  Shaowen Wang

IPC分类号： C07D498/08 ,  C07D498/18 ,  A61K31/436 ,  A61K45/06 ,  A61K31/453

摘要： The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.

公开(公告)号：US11970497B2

公开(公告)日：2024-04-30

申请号：US16973836

申请日：2020-07-31

申请人： Novartis AG

发明人： Chris Adair ,  Tracy Chen ,  Jian Ding ,  Christy Fryer ,  Yuko Isome ,  Marie-Helene Larraufie ,  Katsumasa Nakajima ,  Nik Savage ,  Ariel Sterling Twomey

IPC分类号： C07D471/10 ,  A61P35/00 ,  A61K31/4747

CPC分类号： C07D471/10 ,  A61P35/00 ,  A61K31/4747

摘要： The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.