公开(公告)号：US11672782B2

公开(公告)日：2023-06-13

申请号：US17089064

申请日：2020-11-04

申请人： Novartis AG

发明人： Kamlesh Jagdis Bala ,  Andrew Brearley ,  James Dale ,  Anne-Marie Edwards ,  Mahbub Ahmed ,  David Porter ,  Robert Alexander Pulz ,  Lisa Ann Rooney ,  David Andrew Sandham ,  Duncan Shaw ,  Nichola Smith ,  Jessica Louise Taylor ,  Roger John Taylor ,  Thomas Josef Troxler ,  Joe Wrigglesworth

IPC分类号： A61K31/422 ,  A61K31/4155 ,  C07D413/12 ,  C07D413/14

CPC分类号： A61K31/422 ,  A61K31/4155 ,  C07D413/12 ,  C07D413/14 ,  A61K31/422 ,  A61K2300/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof;




a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US09403810B2

公开(公告)日：2016-08-02

申请号：US14711684

申请日：2015-05-13

申请人： Novartis AG

发明人： Kamlesh Jagdis Bala ,  Andrew Brearley ,  James Dale ,  Anne-Marie Edwards ,  Mahbub Ahmed ,  David Porter ,  Robert Alexander Pulz ,  Lisa Ann Rooney ,  David Andrew Sandham ,  Duncan Shaw ,  Nichola Smith ,  Jessica Louise Taylor ,  Roger John Taylor ,  Thomas Josef Troxler ,  Joe Wrigglesworth

IPC分类号： C07D413/12 ,  C07D413/14 ,  A61K31/4155 ,  A61K31/422

CPC分类号： A61K31/422 ,  A61K31/4155 ,  C07D413/12 ,  C07D413/14 ,  A61K2300/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US10195181B2

公开(公告)日：2019-02-05

申请号：US15184730

申请日：2016-06-16

申请人： Novartis AG

发明人： Kamlesh Jagdis Bala ,  Andrew Brearley ,  James Dale ,  Anne-Marie Edwards ,  Mahbub Ahmed ,  David Porter ,  Robert Alexander Pulz ,  Lisa Ann Rooney ,  David Andrew Sandham ,  Duncan Shaw ,  Nichola Smith ,  Jessica Louise Taylor ,  Roger John Taylor ,  Thomas Josef Troxler ,  Joe Wrigglesworth

IPC分类号： A61K31/422 ,  C07D413/14 ,  A61K31/4155 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.