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    Recognitive Hydrogel
    2.
    发明申请
    Recognitive Hydrogel 有权
    认可水凝胶

    公开(公告)号：US20100151580A1

    公开(公告)日：2010-06-17

    申请号：US12581308

    申请日：2009-10-19

    申请人： Nicholas A. Peppas ,  Carolyn Bayer

    发明人： Nicholas A. Peppas ,  Carolyn Bayer

    IPC分类号： G01N27/02

    CPC分类号： A61K47/59 ,  A61K47/58 ,  Y10T436/143333

    摘要： Novel recognitive hydrogels and sensors are provided, as well as methods of fabricating and using such hydrogels and sensors. Such recognitive hydrogels may comprise a molecularly imprinted polymer having a binding cavity specific for a triggering molecule and a conductive polymer associated with the molecularly imprinted polymer. Such sensors may comprise the recognitive hydrogels and an impedance sensing component. Such methods may comprise providing a triggering molecule, providing a sensor comprising a molecularly imprinted polymer having a binding cavity specific for the triggering molecule, a conductive polymer associated with the molecularly imprinted polymer, and an impedance sensing component, introducing the triggering molecule into the sensor, and detecting a change in impedance of the recognitive hydrogel with the impedance sensing component.

    摘要翻译： 提供了新的识别水凝胶和传感器，以及制造和使用这种水凝胶和传感器的方法。 这种识别水凝胶可以包含具有针对触发分子特异性的结合空穴的分子印迹聚合物和与分子印迹聚合物相关联的导电聚合物。 这种传感器可以包括识别水凝胶和阻抗感测部件。 这样的方法可以包括提供触发分子，提供包含具有针对触发分子特异性的结合腔的分子印迹聚合物的传感器，与分子印迹聚合物相关联的导电聚合物以及将触发分子引入到传感器中的阻抗感测组件 并且使用所述阻抗感测部件检测所述识别水凝胶的阻抗的变化。

    COMPOSITION AND METHOD OF PREPARATION OF RELEASE SYSTEMS FOR CONSTANT (ZERO-ORDER) RELEASE OF ACTIVE AGENTS
    4.
    发明申请
    COMPOSITION AND METHOD OF PREPARATION OF RELEASE SYSTEMS FOR CONSTANT (ZERO-ORDER) RELEASE OF ACTIVE AGENTS 审中-公开
    组合物和释放系统的制备方法，用于活性剂的恒定（零订购）释放

    公开(公告)号：US20090317465A1

    公开(公告)日：2009-12-24

    申请号：US12485710

    申请日：2009-06-16

    申请人： Nicholas A. Peppas

    发明人： Nicholas A. Peppas

    IPC分类号： A61K9/24

    CPC分类号： A61K9/209 ,  A61K9/2072 ,  A61K9/2095

    摘要： The present invention includes methods and compositions for pharmaceutical compositions that exhibit substantially constant release profile. The composition includes at least two layers with different drug to polymer ratios. The layers can be arranged in any order to achieve desirable pharmaceutical effects.

    摘要翻译： 本发明包括表现出基本恒定释放曲线的药物组合物的方法和组合物。 该组合物包括具有不同药物与聚合物比例的至少两层。 这些层可以以任何顺序布置以实现期望的药物效果。

    Mimetic Drug Delivery Systems for Release with Specific Molecular Triggers
    8.
    发明申请
    Mimetic Drug Delivery Systems for Release with Specific Molecular Triggers 审中-公开
    用特定分子触发释放的模拟药物输送系统

    公开(公告)号：US20100210835A1

    公开(公告)日：2010-08-19

    申请号：US12708224

    申请日：2010-02-18

    申请人： Nicholas A. Peppas

    发明人： Nicholas A. Peppas

    IPC分类号： C07H7/00 ,  C07H1/00

    CPC分类号： C08F220/06 ,  C08F222/1006

    摘要： The present invention provides a molecule-imprinted reversible polymeric network composition and methods of making and using the same. In addition, the instant invention provides a composition for the delivery of an active agent. The composition includes a polymer matrix formed from at least a first and a second monomer and one or more active agents deposited within the polymer matrix. One or more recognition sites on at least one of the at least first and second monomers and an active site formed in the polymer matrix by the one or more recognition sites. The template binds to the active site by interacting with at least one of the one or more recognition sites, wherein the template causes the release of the one or more active agents.

    摘要翻译： 本发明提供分子印迹的可逆聚合物网络组合物及其制备和使用方法。 此外，本发明提供了用于递送活性剂的组合物。 组合物包括由至少第一和第二单体形成的聚合物基质和沉积在聚合物基质内的一种或多种活性剂。 至少第一和第二单体中的至少一种上的一个或多个识别位点和由该一个或多个识别位点在聚合物基质中形成的活性位点。 模板通过与一个或多个识别位点中的至少一个相互作用而与活性位点结合，其中模板引起一种或多种活性剂的释放。

    Temperature-Sensitive Nanoparticles for Controlled Drug Delivery
    10.
    发明申请
    Temperature-Sensitive Nanoparticles for Controlled Drug Delivery 审中-公开
    用于控制药物递送的温度敏感性纳米颗粒

    公开(公告)号：US20080138430A1

    公开(公告)日：2008-06-12

    申请号：US11862753

    申请日：2007-09-27

    申请人： Donald E. Owens ,  Nicholas A. Peppas

    发明人： Donald E. Owens ,  Nicholas A. Peppas

    IPC分类号： A61K9/51 ,  A61K47/32

    CPC分类号： A61K9/0009 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5192

    摘要： The present invention generally relates to controlled drug delivery. More specifically, the present invention relates to novel device/system and extracorporeally-controlled method of drug delivery. In some embodiments, the present invention provides a system comprising a thermally-active metal nanoshell; and a temperature-responsive interpenetrating polymer network having at least one therapeutic agent disposed therein; wherein the thermally-active metal nanoshell is proximate to the temperature-responsive interpenetrating polymer network. In some embodiments, the present invention relates to a particle composition comprising a thermally-active metal nanoshell and a temperature-responsive interpenetrating polymer network. A method is also provided comprising: providing a plurality of the particles; and irradiating the particles so as to effect a temperature-induced swelling of the temperature-responsive interpenetrating polymer network.

    摘要翻译： 本发明一般涉及受控药物递送。 更具体地，本发明涉及药物递送的新型装置/系统和体外控制方法。 在一些实施方案中，本发明提供了一种包含热活性金属纳米壳的系统; 和具有置于其中的至少一种治疗剂的温度敏感的互穿聚合物网络; 其中所述热活性金属纳米壳靠近所述温度敏感互穿聚合物网络。 在一些实施方案中，本发明涉及包含热活性金属纳米壳和温度响应互穿聚合物网络的颗粒组合物。 还提供了一种方法，包括：提供多个所述颗粒; 并照射该颗粒以便实现温度响应互穿聚合物网络的温度诱导的溶胀。