公开(公告)号：US20160046593A1

公开(公告)日：2016-02-18

申请号：US14548374

申请日：2014-11-20

Applicant: National Taiwan University

Inventor： YA-CHING SHEN

IPC: C07D307/92 ,  C07C49/743 ,  C07C45/78

CPC classification number: C07D307/92 ,  C07C45/78 ,  C07C45/79 ,  C07C49/743 ,  C07C2602/28

Abstract: The present invention discloses eight new diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of Dysoxylum hongkongense, wherein AMBROX® which is applicable in the perfume industry is prepared from Dysongensin A via a series of chemical reactions, and the cytotoxicity of Dysongensins A to H against human cancer cell lines and their antiviral and anti-inflammatory activities are determined. Therefore, in the present invention, AMBROX® prepared from Dysongensin A is a new idea for application as an odorous compound in the perfume industry, and the novel diterpenoids can be prepared as a pharmaceutical compositions and/or a drug having antiviral, anti-inflammatory and/or anti-cancer activities.

Abstract translation: 本发明公开了从香叶苦参的叶子和枝条提取的八种新的二萜类化合物，即丹参素A至H，其中可应用于香精工业的AMBROX®通过一系列化学反应由丹参素A制备，细胞毒性 测定对人类癌细胞系的依赖菌素A至H及其抗病毒和抗炎活性。 因此，在本发明中，由Densongensin A制备的AMBROX®是在香水工业中作为恶臭化合物应用的新思路，新颖的二萜类化合物可以制备成具有抗病毒，抗炎作用的药物组合物和/或药物 和/或抗癌活动。