公开(公告)号：US20240077552A1

公开(公告)日：2024-03-07

申请号：US18226960

申请日：2023-07-27

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Anna PARKER ,  Stephan KNECHT ,  Tim EICHHORN ,  John BLANCHARD

IPC: G01R33/36 ,  A61K49/10 ,  B01D11/04

CPC classification number: G01R33/3628 ,  A61K49/10 ,  B01D11/04

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

公开(公告)号：US20240361407A1

公开(公告)日：2024-10-31

申请号：US18764964

申请日：2024-07-05

Applicant: NVISION IMAGING TECHNOLOGIES GMBH

Inventor： Ilai SCHWARTZ ,  Anna PARKER ,  Stephan KNECHT ,  Tim EICHHORN ,  John BLANCHARD

IPC: G01R33/36 ,  A61K49/10 ,  B01D11/04

CPC classification number: G01R33/3628 ,  A61K49/10 ,  B01D11/04

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.