公开(公告)号：US20250032788A1

公开(公告)日：2025-01-30

申请号：US18759109

申请日：2024-06-28

Applicant: NOVOCURE GMBH

Inventor： Eyal Dor-On ,  Spencer J. Collis ,  Callum George Jones ,  Ola Rominiyi ,  Lilach Avigdor

IPC: A61N1/36 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/517

Abstract: Disclosed herein is the use of alternating electric fields and a DNA-dependent PK inhibitor to treat cancer. Disclosed herein is the use of alternating electric fields and a DNA-dependent PK inhibitor for inducing cell death. Disclosed herein is the use of alternating electric fields and a DNA-dependent PK inhibitor for inhibiting DNA repair in a cancer cell having double stranded DNA breaks. Disclosed herein is the use of alternating electric fields and a DNA-dependent PK inhibitor for increasing efficacy of radiation therapy.