公开(公告)号：US20230056301A1

公开(公告)日：2023-02-23

申请号：US17785754

申请日：2020-12-15

Applicant: North Carolina State University

Inventor： Ke Cheng ,  Zhenhua Li

IPC: C07K16/24 ,  A61K47/69 ,  A61K47/10 ,  A61P29/00

Abstract: The present disclosure provides compositions and methods relating to the use of platelet microparticles to deliver therapeutic antibodies. In particular, the present disclosure provides novel compositions and methods for treating cardiac injury using anti-IL-1β platelet microparticles (IL1-PMs) to promote cardiac detoxification and repair after cardiac injury (e.g., myocardial infarction).

公开(公告)号：US20230218746A1

公开(公告)日：2023-07-13

申请号：US18001561

申请日：2021-06-15

Applicant: NORTH CAROLINA STATE UNIVERSITY

Inventor： Ke Cheng ,  Phuong-Uyen Cao Dinh ,  Zhenhua Li

IPC: A61K39/215 ,  A61K35/42 ,  A61K38/48 ,  A61K38/17 ,  A61K9/127 ,  A61K31/675 ,  A61K38/21 ,  A61K31/513 ,  A61K31/427 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61K35/42 ,  A61K38/4813 ,  A61K38/1709 ,  A61K38/177 ,  A61K9/127 ,  A61K31/675 ,  A61K38/215 ,  A61K31/513 ,  A61K31/427 ,  A61P31/14 ,  A61K2039/5156

Abstract: The present disclosure provides compositions and methods related to antiviral therapeutics. In particular, the present disclosure provides novel compositions and methods for treating and/or preventing viral infections using vesicles derived from lung spheroid cells (LSCs). LSC-derived vesicles can be used as viral decoy nanoparticles for therapeutic applications, as virus-like particles (VLPs) for vaccine production, and as an antiviral drug delivery platform.