公开(公告)号：US20250009913A1

公开(公告)日：2025-01-09

申请号：US18754452

申请日：2024-06-26

Applicant: NORTH CAROLINA STATE UNIVERSITY

Inventor： Qihui Liu ,  Zhiyuan Wu ,  Jonathan S. Lindsey

IPC: A61K51/04 ,  A61K51/08 ,  A61K51/12

Abstract: Compounds comprising a tetrapyrrole macrocycle that includes a radionuclide; a hydrogelator attached to the tetrapyrrole macrocycle; a water solubilizing group attached to the hydrogelator; and a cleavage site that is between the hydrogelator and the water solubilizing group are described herein along with their methods of use. Two or more compounds of the present invention may two or more compounds may self-assemble (e.g., aggregate), optionally in vivo.