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公开(公告)号：US20220242910A1
公开(公告)日：2022-08-04
申请号：US17579463
申请日：2022-01-19
发明人： Jae Young SEONG , Jong-Ik HWANG , Dong-Hoon KIM , Gi Hoon SON , Yoo-Na LEE , Seongsik YUN , Arfaxad REYES-ALCARAZ
IPC分类号： C07K7/08 , A61P25/28 , A61P25/30 , A61P25/22 , A61P25/18 , A61P25/24 , A61P25/06 , A61K9/00 , A61K9/19
摘要： The present invention relates to spexin-based agonists specific for galanin receptor type 2 and use thereof. More specifically, the present invention provides peptide-based agonists with high specificity for galanin receptor type 2 and improved stability. The peptide-based agonists are involved in the regulation of in vivo physiological functions, such as food intake, anxiety, emotion, and addiction, for which galanin receptors type 2 is responsible, to effectively suppress appetite, help recover from anxiety disorder, and reduce pleasure addiction. Therefore, the peptide-based agonists can be used to prevent or treat galanin receptor type 2-mediated diseases.
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公开(公告)号：US20200010509A1
公开(公告)日：2020-01-09
申请号：US16511976
申请日：2019-07-15
发明人： Jae Young SEONG , Jong-Ik HWANG , Dong-Hoon KIM , Gi Hoon SON , Yoo-Na LEE , Seongsik YUN , Arfaxad REYES-ALCARAZ
IPC分类号： C07K7/08 , A61K9/19 , A61K9/00 , A61P25/06 , A61P25/24 , A61P25/18 , A61P25/22 , A61P25/30 , A61P25/28
摘要： The present invention relates to spexin-based agonists specific for galanin receptor type 2 and use thereof. More specifically, the present invention provides peptide-based agonists with high specificity for galanin receptor type 2 and improved stability. The peptide-based agonists are involved in the regulation of in vivo physiological functions, such as food intake, anxiety, emotion, and addiction, for which galanin receptors type 2 is responsible, to effectively suppress appetite, help recover from anxiety disorder, and reduce pleasure addiction. Therefore, the peptide-based agonists can be used to prevent or treat galanin receptor type 2-mediated diseases.
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