专利检索 ap:("NEO-NANOMEDICS, INC.") AND inv:"Seong Tae Bae" 第 1 页

1.

发明授权
Iron oxide nanoparticles doped with alkali metals or alkali earth metals capable of gigantic AC magnetic self-heating in biocompatible AC magnetic field and method of preparing the same 有权

公开(公告)号：US10577254B2

公开(公告)日：2020-03-03

申请号：US15788782

申请日：2017-10-19

申请人： NEO-NANOMEDICS, INC.

发明人： Seong Tae Bae , Jung Tak Jang

IPC分类号： C01G49/06 , A61K41/00 , B82Y5/00 , B82Y25/00 , B82Y40/00 , H01F1/00 , H01F1/36

摘要： Disclosed herein are iron oxide nanoparticles prepared through high-temperature thermal decomposition of an Fe3+ precursor and an M+ or M2+ (M=Li, Na, K, Mg, and Ca) precursor in an oxygen atmosphere. The iron oxide nanoparticles are nanoparticles, in which an alkali metal or alkali earth metal is doped into an Fe vacancy site of γ-Fe2O3, and generate explosive heat even in a biocompatible low AC magnetic field. Through both in vitro and in vivo tests, it was proven that cancer cells could be killed by performing low-frequency hyperthermia using the iron oxide nanoparticles set forth above.