公开(公告)号：US20190030208A1

公开(公告)日：2019-01-31

申请号：US16152399

申请日：2018-10-04

申请人： NATIONAL CHUNG HSING UNIVERSITY

发明人： Shu-Ping Lin ,  Pei-Chieh Wong

IPC分类号： A61L27/34 ,  A61L31/10 ,  A61F2/82 ,  A61L31/02

摘要： The present invention relates to a surface modification method for improving the hemocompatibility of a biomedical metallic substrate, comprising: fixing a sulfur-containing and nitrogen-containing monolayer film on the surface of oxide layer of the biomedical metallic substrate by molecular self-assembly. The surface modification improves the hydrophilicity and hemocompatibility of the biomedical metallic substrate in contact with the blood, and ensures that the biomedical metallic substrate is non-toxic to the endothelial cells.

公开(公告)号：US20170065748A1

公开(公告)日：2017-03-09

申请号：US15256751

申请日：2016-09-06

申请人： NATIONAL CHUNG-HSING UNIVERSITY

发明人： Shu-Ping Lin ,  Pei-Chieh Wong

IPC分类号： A61L31/08 ,  A61F2/82 ,  A61F2/06 ,  A61L31/02

CPC分类号： A61F2/06 ,  A61F2/82 ,  A61F2240/001 ,  A61F2310/0061 ,  A61F2310/00856 ,  A61F2310/00916 ,  A61L31/022 ,  A61L31/14 ,  A61L33/0076 ,  A61L2400/18

摘要： The present invention relates to a surface modification method for improving the hemocompatibility of biomedical metallic substrate, comprising: fixing a sulfur-containing monomolecular film on the surface of oxide layer of a biomedical metallic substrate by molecular self-assembly. The surface modification will improve the hydrophilicity and hemocompatibility of the biomedical metallic substrate in contact with the blood, and ensure that the biomedical metallic substrate is non-toxic to the endothelial cells.

摘要翻译： 本发明涉及一种用于改善生物医学金属基质的血液相容性的表面改性方法，包括：通过分子自组装将含硫单分子膜固定在生物医学金属基底的氧化物层的表面上。 表面改性将改善与血液接触的生物医学金属底物的亲水性和血液相容性，并确保生物医学金属底物对内皮细胞无毒性。