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公开(公告)号：US20170312351A1
公开(公告)日：2017-11-02
申请号：US15468046
申请日：2017-03-23
Applicant: NANTCELL, INC. , Nant Holdings IP, LLC
Inventor： Kayvan Niazi , Andrew Nguyen , Shahrooz Rabizadeh , Patrick Soon-Shiong , Stephen Charles Benz
CPC classification number: A61K39/0011 , A61K39/39 , A61K2039/5254 , A61K2039/5256 , A61K2039/57 , A61K2039/572 , A61K2039/70 , C07K7/06 , C07K14/70539 , C07K14/70596 , C07K2319/01 , C07K2319/06 , C07K2319/40 , C07K2319/95 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10334 , C12N2710/10343 , C12N2840/002 , G16B20/00
Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate a recombinant polytope that is optimized for proper trafficking and processing. In preferred methods, the polytope is encoded in a viral expression system that is used as a therapeutic agent.
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Patent Agency Ranking
公开(公告)号：US12224064B2
公开(公告)日：2025-02-11
申请号：US17789590
申请日：2021-01-11
Applicant: NantCell, Inc. , NantOmics, LLC , NantHealth, Inc.
Inventor： Mustafa I. Jaber , Christopher W. Szeto , Liudmila A. Beziaeva , Stephen Charles Benz
IPC: G16H50/20 , G06F18/2413 , G06T7/00 , G06V20/69 , G16H30/40
Abstract: A method of determining a clinical value for an individual based on a tumor in an image by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to determine a lymphocyte distribution of lymphocytes in the tumor based on the image; apply a classifier to the lymphocyte distribution to classify the tumor, the classifier having been trained to classify tumors into a class selected from at least two classes respectively associated with lymphocyte distributions; and determine the clinical value for the individual based on prognoses of individuals with tumors in the class into which the classifier classified the tumor.
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公开(公告)号：US11948687B2
公开(公告)日：2024-04-02
申请号：US17381675
申请日：2021-07-21
Applicant: NantOmics, LLC , NantHealth, Inc. , NantCell, Inc.
Inventor： Mustafa I. Jaber , Liudmila A. Beziaeva , Bing Song , Christopher W. Szeto , Stephen Charles Benz , Shahrooz Rabizadeh
CPC classification number: G16H50/20 , G06N3/08 , G06T7/0012 , G06T7/11 , G06T2207/30096
Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.
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公开(公告)号：US12224066B2
公开(公告)日：2025-02-11
申请号：US18431151
申请日：2024-02-02
Applicant: NantOmics, LLC , NantHealth, Inc. , NantCell, Inc.
Inventor： Mustafa I. Jaber , Bing Song , Christopher W. Szeto , Stephen Charles Benz , Shahrooz Rabizadeh , Liudmila A. Beziaeva
Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.
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公开(公告)号：US11221328B2
公开(公告)日：2022-01-11
申请号：US16491559
申请日：2018-03-07
Applicant: NANTCELL, INC.
Inventor： Patrick Soon-Shiong , Shahrooz Rabizadeh , Kayvan Niazi , Stephen Charles Benz , Laurent H. Boissel , Hans Klingemann , Barry J. Simon
IPC: C12Q1/6886 , G01N33/50 , G16H50/30 , C12N5/0783
Abstract: Detection of under-expression of selected genes in NK cells is used to confirm a hypoxic tumor microenvironment that is ordinarily suppressive with respect to ADCC and cytotoxic cell killing of NK cells. Most notably, while hypoxia is known to upregulate HIF-1α and genes under the control of HIF-1α, hypoxia in a tumor microenvironment led to under-expression of selected genes, including HIF-1α. Thus, gene expression analysis of certain genes on NK cells can be used to detect conditions in a tumor that would indicate use of haNK cells.
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公开(公告)号：US11154597B2
公开(公告)日：2021-10-26
申请号：US15468046
申请日：2017-03-23
Applicant: NANTCELL, INC. , NANT HOLDINGS IP, LLC , NANTOMICS, LLC
Inventor： Kayvan Niazi , Andrew Nguyen , Shahrooz Rabizadeh , Patrick Soon-Shiong , Stephen Charles Benz
IPC: A61K39/00 , A61K39/39 , C07K7/06 , C07K14/74 , C07K14/705 , C12N7/00 , C12N15/86 , G16B20/00 , G16B20/20
Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate a recombinant polytope that is optimized for proper trafficking and processing. In preferred methods, the polytope is encoded in a viral expression system that is used as a therapeutic agent.
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