公开(公告)号：US20220218713A1

公开(公告)日：2022-07-14

申请号：US17702304

申请日：2022-03-23

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Mang ,  Werner Heilmayer ,  Rudolf Badegruber ,  Dirk Strickmann ,  Rodger Novak ,  Mathias Ferencic ,  Atchyuta Rama Chandra Murty Bulusu

IPC: A61K31/5375 ,  C07C323/52 ,  A61K31/215 ,  A61K31/357 ,  C07C323/61 ,  C07D295/096 ,  C07D317/72

Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed

公开(公告)号：US20240208989A1

公开(公告)日：2024-06-27

申请号：US18286958

申请日：2022-04-15

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Riedl ,  Susanne Paukner ,  Wolfgang Wicha ,  Klaus Thirring ,  Dirk Strickmann ,  Michael Hafner

IPC: C07D493/04 ,  A61K31/443 ,  A61K31/497 ,  A61K31/506 ,  A61P31/04

CPC classification number: C07D493/04 ,  A61K31/443 ,  A61K31/497 ,  A61K31/506 ,  A61P31/04

Abstract: A compound of formula (I)






wherein R1 is










wherein A is hydrogen atom or a (C1-6)alkyl, and
wherein any Q is independently from each other a nitrogen atom or CH,
wherein R2 is










the compound for use as a medicament and a pharmaceutical composition comprising the compound as well as a method of treatment or prevention a disease mediated by microbes making use thereof.

公开(公告)号：US20200030335A1

公开(公告)日：2020-01-30

申请号：US16593449

申请日：2019-10-04

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Mang ,  Werner Heilmayer ,  Rudolf Badegruber ,  Dirk Strickmann ,  Rodger Novak ,  Mathias Ferencic ,  Atchyuta Rama Chandra Murty Bulusu

IPC: A61K31/5375 ,  C07C323/52 ,  A61K31/215 ,  A61K31/357 ,  C07C323/61 ,  C07D295/096 ,  C07D317/72

Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2′, and if m=1 then R3 is on position 1′); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl; R2 is hydrogen or —(C3-6)cycloalkyl, or —unsubstituted (C1-6)alkyl, or —(C1-6)alkyl substituted by one or more of —hydroxy; preferably one or two, —methoxy, —halogen, —(C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e.g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or —with the proviso that R3 is bound to 2′ R3 represents —O—(CH2)P—O— with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.

公开(公告)号：US20180303842A1

公开(公告)日：2018-10-25

申请号：US16023880

申请日：2018-06-29

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Mang ,  Werner Heilmayer ,  Rudolf Badegruber ,  Dirk Strickmann ,  Rodger Novak ,  Mathias Ferencic ,  Atchyuta Rama Chandra Murty Bulusu

IPC: A61K31/5375 ,  A61K31/357 ,  C07C323/52 ,  C07D295/096 ,  C07D317/72 ,  C07C323/61 ,  A61K31/215

CPC classification number: A61K31/5375 ,  A61K31/215 ,  A61K31/357 ,  C07C323/52 ,  C07C323/61 ,  C07C2601/14 ,  C07C2603/99 ,  C07D295/096 ,  C07D317/72

Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:

公开(公告)号：US20210113571A1

公开(公告)日：2021-04-22

申请号：US17138097

申请日：2020-12-30

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Mang ,  Werner Heilmayer ,  Rudolf Badegruber ,  Dirk Strickmann ,  Rodger Novak ,  Mathias Ferencic ,  Atchyuta Rama Chandra Murty Bulusu

IPC: A61K31/5375 ,  C07C323/52 ,  A61K31/215 ,  A61K31/357 ,  C07C323/61 ,  C07D295/096 ,  C07D317/72

Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed

公开(公告)号：US20200281933A1

公开(公告)日：2020-09-10

申请号：US16881117

申请日：2020-05-22

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Mang ,  Werner Heilmayer ,  Rudolf Badegruber ,  Dirk Strickmann ,  Rodger Novak ,  Mathias Ferencic ,  Atchyuta Rama Chandra Murty Bulusu

IPC: A61K31/5375 ,  C07C323/52 ,  A61K31/215 ,  A61K31/357 ,  C07C323/61 ,  C07D295/096 ,  C07D317/72

Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:

公开(公告)号：US20190175603A1

公开(公告)日：2019-06-13

申请号：US16277143

申请日：2019-02-15

Applicant: NABRIVA THERAPEUTICS GMBH

Inventor： Rosemarie Mang ,  Werner Heilmayer ,  Rudolf Badegruber ,  Dirk Strickmann ,  Rodger Novak ,  Mathias Ferencic ,  Atchyuta Rama Chandra Murty Bulusu

IPC: A61K31/5375 ,  C07D295/096 ,  A61K31/215 ,  C07D317/72 ,  C07C323/52 ,  C07C323/61 ,  A61K31/357

Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed: