公开(公告)号：US20230357406A1

公开(公告)日：2023-11-09

申请号：US18180785

申请日：2023-03-08

Applicant: Molecular Templates, Inc.

Inventor： Eric POMA ,  Erin WILLERT ,  Aimee IBERG ,  Swati KHANNA ,  Roger WALTZMAN ,  Kogan BAO

IPC: C07K16/28 ,  C07K14/245 ,  C07K14/25 ,  A61P35/00

CPC classification number: C07K16/2818 ,  C07K14/245 ,  C07K14/25 ,  A61P35/00 ,  C07K2317/569 ,  C07K2319/00 ,  A61K2039/545

Abstract: Provided herein are binding molecules that each comprise (1) a Shiga toxin A subunit effector polypeptide and (2) a binding region capable of specifically binding CTLA-4 on the surface of cell, such as a tumor cell or an immunosuppressive immune cell. Further provided are methods of using such binding molecules to treat diseases and disorders, such as cancer.

公开(公告)号：US20230295342A1

公开(公告)日：2023-09-21

申请号：US18006216

申请日：2021-07-22

Applicant: Eric POMA ,  Roger WALTZMAN ,  Jack HIGGINS ,  Eric WILLIAMS ,  Molecular Templates, Inc.

Inventor： Eric POMA ,  Roger WALTZMAN ,  Jack HIGGINS ,  Eric WILLIAMS

IPC: C07K16/32 ,  A61K47/68 ,  A61P35/00

CPC classification number: C07K16/32 ,  A61K47/6829 ,  A61P35/00 ,  A61K2039/505

Abstract: Provided herein are methods for treating or preventing cancer comprising administering to a subject in need thereof an effective amount of a HER2 binding molecule comprising a cytotoxic Shiga toxin A subunit effector polypeptide and a binding region capable of specifically binding an extracellular part of human HER2. The cancer may be a cancer that involves a cell which expresses or overexpresses HER2, such as a HER2-positive breast cancer, bile duct cancer, or a gastric or gastroesophageal adenocarcinoma.