公开(公告)号：US20100087655A1

公开(公告)日：2010-04-08

申请号：US12450730

申请日：2008-04-17

申请人： Mitsuru Takase ,  Fuminori Komatsu

发明人： Mitsuru Takase ,  Fuminori Komatsu

IPC分类号： C07D233/88 ,  C07C249/02

CPC分类号： C07D233/90 ,  C07C257/06 ,  C07C257/12

摘要： A method for producing N-(2-amino-1,2-dicyanovinyl)imidates represented by the following formula (1-III) under low temperature conditions within a short period of time in high yield is provided. In addition, a method for producing N-(2-amino-1,2-dicyanovinyl)formamidine represented by the following formula (2-II) which is suitably applicable to a cyclization reaction for producing AICN, AICA or the like and which enhances yield of the cyclization reaction is provided. In addition, a method for producing aminoimidazole derivatives represented by the following formula (3-V) in high yield by using diaminomaleonitrile as a starting material is provided.

摘要翻译： 提供了在低温条件下以高产率在短时间内生产由下式（1-III）表示的N-（2-氨基-1,2-二氰基乙烯基）亚胺酯的方法。 另外，由下述式（2-II）表示的N-（2-氨基-1,2-二氰基乙烯基）甲脒的制造方法适用于制造AICN，AICA等的环化反应， 提供了环化反应的产率。 此外，提供了通过使用二氨基马来腈作为原料以高产率制备由下式（3-V）表示的氨基咪唑衍生物的方法。

公开(公告)号：US08258333B2

公开(公告)日：2012-09-04

申请号：US13363062

申请日：2012-01-31

申请人： Mitsuru Takase ,  Fuminori Komatsu

发明人： Mitsuru Takase ,  Fuminori Komatsu

IPC分类号： C07C257/22

CPC分类号： C07D233/90 ,  C07C257/06 ,  C07C257/12

摘要： A method for producing N-(2-amino-1,2-dicyanovinyl)formamidine, including the steps of reacting an N-(2-amino-1,2-dicyanovinyl)formimidate and ammonia by adding aqueous ammonia to a solution or suspension of an N-(2-amino-1,2-dicyanovinyl)formimidate in ether, or alternatively directly adding an N-(2-amino-1,2-dicyanovinyl)formimidate or adding a solution or suspension of an N-(2-amino-1,2-dicyanovinyl)formimidate in ether to a liquid containing ether and aqueous ammonia.

摘要翻译： 一种制备N-（2-氨基-1,2-二氰基乙烯基）甲脒的方法，包括以下步骤：通过向溶液或悬浮液中加入氨水使N-（2-氨基-1,2-二氰基乙烯基）亚甲酰亚胺与氨反应 的N-（2-氨基-1,2-二氰基乙烯基）亚甲酰亚胺在乙醚中的溶液或悬浮液，或者直接加入N-（2-氨基-1,2-二氰基乙烯基）亚甲酰亚胺酯，或加入N- - 氨基-1,2-二氰基乙烯基）亚甲基酯在乙醚中的溶液与含有乙醚和氨水的液体混合。

公开(公告)号：US08785654B2

公开(公告)日：2014-07-22

申请号：US13363091

申请日：2012-01-31

申请人： Mitsuru Takase ,  Fuminori Komatsu

发明人： Mitsuru Takase ,  Fuminori Komatsu

IPC分类号： C07D233/88

CPC分类号： C07D233/90 ,  C07C257/06 ,  C07C257/12

摘要： A method for producing N-(2-amino-1,2-dicyanovinyl)imidates represented by the following formula (1-III) under low temperature conditions within a short period of time in high yield is provided. In addition, a method for producing N-(2-amino-1,2-dicyanovinyl)formamidine represented by the following formula (2-II) which is suitably applicable to a cyclization reaction for producing AlCN, AlCA or the like and which enhances yield of the cyclization reaction is provided. In addition, a method for producing aminoimidazole derivatives represented by the following formula (3-V) in high yield by using diaminomaleonitrile as a starting material is provided.

摘要翻译： 提供了在低温条件下以高产率在短时间内生产由下式（1-III）表示的N-（2-氨基-1,2-二氰基乙烯基）亚胺酯的方法。 另外，由下述式（2-II）表示的N-（2-氨基-1,2-二氰基乙烯基）甲脒的制造方法可适用于制造AlCN，AlCA等的环化反应， 提供了环化反应的产率。 此外，提供了通过使用二氨基马来腈作为原料以高产率制备由下式（3-V）表示的氨基咪唑衍生物的方法。

公开(公告)号：US08273899B2

公开(公告)日：2012-09-25

申请号：US12450730

申请日：2008-04-17

申请人： Mitsuru Takase ,  Fuminori Komatsu

发明人： Mitsuru Takase ,  Fuminori Komatsu

IPC分类号： C07D233/88 ,  C07C255/09

CPC分类号： C07D233/90 ,  C07C257/06 ,  C07C257/12

摘要： A method for producing N-(2-amino-1,2-dicyanovinyl)imidates represented by the following formula (1-III) under low temperature conditions within a short period of time in high yield is provided. In addition, a method for producing N-(2-amino-1,2-dicyanovinyl)formamidine represented by the following formula (2-II) which is suitably applicable to a cyclization reaction for producing AICN, AICA or the like and which enhances yield of the cyclization reaction is provided. In addition, a method for producing aminoimidazole derivatives represented by the following formula (3-V) in high yield by using diaminomaleonitrile as a starting material is provided.

摘要翻译： 提供了在低温条件下以高产率在短时间内生产由下式（1-III）表示的N-（2-氨基-1,2-二氰基乙烯基）亚胺酯的方法。 另外，由下述式（2-II）表示的N-（2-氨基-1,2-二氰基乙烯基）甲脒的制造方法适用于制造AICN，AICA等的环化反应， 提供了环化反应的产率。 此外，提供了通过使用二氨基马来腈作为原料以高产率制备由下式（3-V）表示的氨基咪唑衍生物的方法。

公开(公告)号：US07358356B2

公开(公告)日：2008-04-15

申请号：US10529392

申请日：2003-10-02

申请人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

发明人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

IPC分类号： C07D499/18

CPC分类号： C07D499/893 ,  C07D499/88

摘要： The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

摘要翻译： 本发明提供了一种制备有机化合物的方法，该方法包括从含有有机化合物和水的极性有机溶剂溶液中蒸馏出水以使水的浓度低于给定水平的脱水步骤，其中脱水步骤包括蒸馏 将极性有机溶剂与极性有机溶剂一起加入到溶液中，或者包括重复多次向溶液中加入极性有机溶剂，然后与极性有机溶剂一起蒸馏出水。 本发明还提供有机化合物的制备，其能够以高分离产率从含有有机化合物的极性有机溶剂溶液，水和必要时的化合物在接触时产生高分离产物。 用水等加速有机化合物分解的物质。

公开(公告)号：US07041820B2

公开(公告)日：2006-05-09

申请号：US10473297

申请日：2002-03-29

申请人： Toshiyuki Watai ,  Mitsuru Takase ,  Takahiro Sagae ,  Shigeo Mori ,  Noriaki Kawahara

发明人： Toshiyuki Watai ,  Mitsuru Takase ,  Takahiro Sagae ,  Shigeo Mori ,  Noriaki Kawahara

IPC分类号： C07D499/08

CPC分类号： C07D499/88 ,  C07D317/40 ,  C07D499/00

摘要： There is provided a method by which various compounds (1) having a carboxyl group in the molecule have the carboxyl group converted to a (dioxolenon-4-yl)methyl ester at low cost, in a simple way and at high yield.The process for producing compounds of formula (3) according to the reaction scheme shown below comprises reacting carboxylic acids of formula (1) with 4-chloromethyldioxolenone compounds of formula (2) in a solvent in the presence of both a phase transfer catalyst and a metal iodide: [where Q represents an organic group, M represents a hydrogen atom, an alkali metal, an alkaline earth metal or a transition metal, R1 and R2 represent a hydrogen atom, an optionally substituted (C1-6 alkyl group or phenyl group)].

摘要翻译： 提供了以简单的方式和高产率，分子中具有羧基的各种化合物（1）以低成本将羧基转化为（二氧戊环-4-基）甲酯的方法。 根据下述反应路线制备式（3）化合物的方法包括使式（1）的羧酸与式（2）的4-氯甲基二氧戊烯酮化合物在溶剂中在相转移催化剂和 金属碘化物：[其中Q表示有机基团，M表示氢原子，碱金属，碱土金属或过渡金属，R 1和R 2表示 氢原子，任选取代的（C 1-6烷基或苯基）]。

公开(公告)号：US20060058521A1

公开(公告)日：2006-03-16

申请号：US10529392

申请日：2003-10-02

申请人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

发明人： Mitsuru Takase ,  Takahiro Sagae ,  Hiroyuki Yazaki ,  Shigeo Mori ,  Daisuke Asanuma

IPC分类号： C07D205/02

CPC分类号： C07D499/893 ,  C07D499/88

摘要： The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given level, wherein the dehydration step comprises distilling off water together with the polar organic solvent while adding a polar organic solvent to the solution, or comprises repeating several cycles of adding a polar organic solvent to the solution and then distilling off water together with the polar organic solvent. The present invention further provides the preparation of an organic compound, which enables efficient isolation of the target product in high isolated yield from a polar organic solvent solution containing the organic compound, water and, if necessary, a compound which produces, upon coming into contact with water or the like, a substance accelerating the decomposition of the organic compound.

摘要翻译： 本发明提供了一种制备有机化合物的方法，该方法包括从含有有机化合物和水的极性有机溶剂溶液中蒸馏出水以使水的浓度低于给定水平的脱水步骤，其中脱水步骤包括蒸馏 将极性有机溶剂与极性有机溶剂一起加入到溶液中，或者包括重复多次向溶液中加入极性有机溶剂，然后与极性有机溶剂一起蒸馏出水。 本发明还提供有机化合物的制备，其能够以高分离产率从含有有机化合物的极性有机溶剂溶液，水和必要时的化合物在接触时产生高分离产物。 用水等加速有机化合物分解的物质。

公开(公告)号：US06797828B1

公开(公告)日：2004-09-28

申请号：US10088425

申请日：2002-03-15

申请人： Hiroaki Shibasaki ,  Fumihiko Nagasaki ,  Mitsuru Takase ,  Satoru Yamazaki ,  Yutaka Ishii ,  Kimihiko Oohata

发明人： Hiroaki Shibasaki ,  Fumihiko Nagasaki ,  Mitsuru Takase ,  Satoru Yamazaki ,  Yutaka Ishii ,  Kimihiko Oohata

IPC分类号： C07D23370

CPC分类号： C07C257/14 ,  C07D233/90

摘要： The invention provides novel processes for preparing efficiently compounds of general formula (1) (wherein R1 and R2 are each independently hydrogen, optionally substituted C1-C10 alkyl, C3-C14 hydrocarbyl bearing alicyclic skeleton, or the like) and initermediates thereof. Compounds of general formula (I) can be prepared by subjecting compounds of general formula (II) and/or salts thereof to cyclization hydrolysis in an aqueous basic solution. Further, compounds of general formula (II) can be prepared from industrially easily available diaminomaleonitrile in a high yield.

摘要翻译： 本发明提供有效制备通式（1）化合物（其中R 1和R 2各自独立地为氢，任选取代的C 1 -C 10烷基，C 3 -C 14烃基带有脂环骨架等）的化合物及其初始化物的新方法。 通式（I）的化合物可以通过使通式（II）的化合物和/或其盐在碱性水溶液中进行环化水解来制备。 此外，通式（II）的化合物可以从工业上容易获得的二氨基马来腈以高产率制备。

公开(公告)号：US06462195B1

公开(公告)日：2002-10-08

申请号：US09622906

申请日：2000-09-05

申请人： Mitsuru Takase ,  Yasuyuki Miyazawa ,  Shiro Tsubokura

发明人： Mitsuru Takase ,  Yasuyuki Miyazawa ,  Shiro Tsubokura

IPC分类号： C07D23952

CPC分类号： C07D239/52

摘要： Compounds having one or more structures represented by general formula (I) as partial structure thereof, which are typified by pyrimidone and pyridone compounds, have two or more reaction sites in alkylation reactions. Accordingly, there is no process for producing O-alkylated products of these compounds at a high selectivity or such processes, if any, are applicable exclusively to those having limited structures. A process for selectivity O-alkylating such a compound as described above by converting it into the copper salt by using a monovalent copper compound such as copper suboxide and then reacting it with an alkylating agent having a leaving group in the presence of a phosphorus compound such as a phosphite. Pyrimidyloxy derivatives or pyridyloxy derivatives obtained by this reaction is useful as intermediates of pesticides or drugs.

摘要翻译： 具有一种或多种由通式（I）表示的结构的化合物作为其部分结构，以嘧啶酮和吡啶酮化合物为代表，在烷基化反应中具有两个或多个反应位点。 因此，没有高选择性地生产这些化合物的O-烷基化产物的方法，或者这些方法（如果有的话）仅专门用于具有有限结构的方法。 通过使用一价铜化合物如低辛氧化物将其转化为铜盐，然后在磷化合物存在下使其与具有离去基团的烷基化剂反应，将上述化合物选择性O-烷基化的方法O-烷基化， 作为亚磷酸酯。 通过该反应获得的嘧啶氧基衍生物或吡啶氧基衍生物可用作农药或药物的中间体。