公开(公告)号：US08452357B2

公开(公告)日：2013-05-28

申请号：US12575802

申请日：2009-10-08

Applicant: Mihailo V. Rebec ,  Michael P. Houlne

Inventor： Mihailo V. Rebec ,  Michael P. Houlne

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14546

Abstract: A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.

公开(公告)号：US08452365B2

公开(公告)日：2013-05-28

申请号：US11920599

申请日：2006-05-24

Applicant: Mihailo V. Rebec ,  Michael P. Houlne

Inventor： Mihailo V. Rebec ,  Michael P. Houlne

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/0238 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/0668

Abstract: A non-invasive method of determining the concentration of an analyte uses Raman spectral information. A high-intensity, narrow band of light (10) is applied to one side (12a) of skin tissue (12). The high-intensity light (10) enters the skin tissue and generates a Raman signal (16). A reflective material (22) is placed in a location nearest the other side (12b) of skin tissue (12). The reflective material (22) is located generally opposite of the entry (A) of the applied high-intensity light (10). The high-intensity light (10) and the Raman signal (20) that pass through the skin tissue (12) are reflected back into the skin tissue (12) via the reflective material (22). The Raman signal (16,20) is collected and the analyte concentration is determined using the collected Raman signal (16,20).

Abstract translation: 确定分析物浓度的非侵入性方法使用拉曼光谱信息。 将高强度，窄带光（10）施加到皮肤组织（12）的一侧（12a）。 高强度光（10）进入皮肤组织并产生拉曼信号（16）。 反射材料（22）被放置在最接近皮肤组织（12）的另一侧（12b）的位置。 反射材料（22）大致与施加的高强度光（10）的入口（A）相对。 穿过皮肤组织（12）的高强度光（10）和拉曼信号（20）经由反射材料（22）反射回皮肤组织（12）。 收集拉曼信号（16,20），并使用收集的拉曼信号（16,20）确定分析物浓度。

公开(公告)号：US20090177052A1

公开(公告)日：2009-07-09

申请号：US11920599

申请日：2006-05-24

Applicant: Mihailo V. Rebec ,  Michael P. Houlne

Inventor： Mihailo V. Rebec ,  Michael P. Houlne

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/0238 ,  G01N21/65 ,  G01N21/658 ,  G01N2201/0668

Abstract: A non-invasive method of determining the concentration of an analyte uses Raman spectral information. A high-intensity, narrow band of light (10) is applied to one side (12a) of skin tissue (12). The high-intensity light (10) enters the skin tissue and generates a Raman signal (16). A reflective material (22) is placed in a location nearest the other side (12b) of skin tissue (12). The reflective material (22) is located generally opposite of the entry (A) of the applied high-intensity light (10). The high-intensity light (10) and the Raman signal (20) that pass through the skin tissue (12) are reflected back into the skin tissue (12) via the reflective material (22). The Raman signal (16,20) is collected and the analyte concentration is determined using the collected Raman signal (16,20).

Abstract translation: 确定分析物浓度的非侵入性方法使用拉曼光谱信息。 将高强度，窄带光（10）施加到皮肤组织（12）的一侧（12a）。 高强度光（10）进入皮肤组织并产生拉曼信号（16）。 反射材料（22）被放置在最接近皮肤组织（12）的另一侧（12b）的位置。 反射材料（22）大致与施加的高强度光（10）的入口（A）相对。 穿过皮肤组织（12）的高强度光（10）和拉曼信号（20）经由反射材料（22）反射回皮肤组织（12）。 收集拉曼信号（16,20），并使用收集的拉曼信号（16,20）确定分析物浓度。

公开(公告)号：US07944556B2

公开(公告)日：2011-05-17

申请号：US12722043

申请日：2010-03-11

Applicant: James E. Smous ,  Mihailo V. Rebec ,  Michael P. Houlne

Inventor： James E. Smous ,  Mihailo V. Rebec ,  Michael P. Houlne

IPC: G01J3/44 ,  G01N21/64 ,  G01N21/65

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14556 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423

Abstract: A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.

Abstract translation: 对光学像差校正光谱图像。 组织暴露于高强度，窄带光。 窄带光被组织中的至少一种分析物散射。 拉曼信号从散射光中被光学收集。 拉曼信号被引导到波长分离装置。 作为强度和波长的函数检测拉曼信号以产生光谱图像。 使用软件算法对光学像差校正光谱图像以空间重新分配强度。 该软件可以适于使用参考图像进行动态校正。 也可以收集荧光信号。

公开(公告)号：US20100226549A1

公开(公告)日：2010-09-09

申请号：US12722043

申请日：2010-03-11

Applicant: JAMES E. SMOUS ,  Mihailo V. Rebec ,  Michael P. Houlne

Inventor： JAMES E. SMOUS ,  Mihailo V. Rebec ,  Michael P. Houlne

IPC: G06K9/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14556 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423

Abstract: A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.

Abstract translation: 对光学像差校正光谱图像。 组织暴露于高强度，窄带光。 窄带光被组织中的至少一种分析物散射。 拉曼信号从散射光中被光学收集。 拉曼信号被引导到波长分离装置。 作为强度和波长的函数检测拉曼信号以产生光谱图像。 使用软件算法对光学像差校正光谱图像以空间重新分配强度。 该软件可以适于使用参考图像进行动态校正。 也可以收集荧光信号。

公开(公告)号：US07705980B2

公开(公告)日：2010-04-27

申请号：US11894511

申请日：2007-08-21

Applicant: James E. Smous ,  Mihailo V. Rebec ,  Michael P. Houlne

Inventor： James E. Smous ,  Mihailo V. Rebec ,  Michael P. Houlne

IPC: G01J3/44 ,  G01N21/64 ,  G01N21/65

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14556 ,  G01N21/6456 ,  G01N21/65 ,  G01N2021/6423

Abstract: A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.

Abstract translation: 对光学像差校正光谱图像。 组织暴露于高强度，窄带光。 窄带光被组织中的至少一种分析物散射。 拉曼信号从散射光中被光学收集。 拉曼信号被引导到波长分离装置。 作为强度和波长的函数检测拉曼信号以产生光谱图像。 使用软件算法对光学像差校正光谱图像以空间重新分配强度。 该软件可以适于使用参考图像进行动态校正。 也可以收集荧光信号。

公开(公告)号：US20100022860A1

公开(公告)日：2010-01-28

申请号：US12575802

申请日：2009-10-08

Applicant: Mihailo V. Rebec ,  Michael P. Houlne

Inventor： Mihailo V. Rebec ,  Michael P. Houlne

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14546

Abstract: A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.

Abstract translation: 确定分析物浓度的非侵入性方法使用拉曼或荧光光谱信息。 将高强度光带施加到皮肤组织的一侧。 高强度光进入皮肤组织并产生拉曼或荧光信号。 将拉曼生成材料或荧光发生材料置于最接近皮肤组织另一侧的位置。 拉曼生成或荧光发生材料大体上与施加的高强度光的入口相对。 收集拉曼或荧光信号，并使用收集的拉曼信号确定分析物浓度。

公开(公告)号：US07603151B2

公开(公告)日：2009-10-13

申请号：US11894510

申请日：2007-08-21

Applicant: Mihailo V. Rebec ,  Michael P. Houlne

Inventor： Mihailo V. Rebec ,  Michael P. Houlne

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/14546

Abstract: A non-invasive method of determining the concentration of an analyte uses Raman or fluorescence spectral information. A high-intensity band of light is applied to one side of skin tissue. The high-intensity light enters the skin tissue and generates a Raman or fluorescence signal. A Raman-generating material or fluorescence-generating material is placed in a location nearest the other side of skin tissue. The Raman-generating or fluorescence-generating material is located generally opposite of the entry of the applied high-intensity light. The Raman or fluorescence signal is collected and the analyte concentration is determined using the collected Raman signal.

Abstract translation: 确定分析物浓度的非侵入性方法使用拉曼或荧光光谱信息。 将高强度光带施加到皮肤组织的一侧。 高强度光进入皮肤组织并产生拉曼或荧光信号。 将拉曼生成材料或荧光发生材料置于最接近皮肤组织另一侧的位置。 拉曼生成或荧光发生材料大体上与施加的高强度光的入口相对。 收集拉曼或荧光信号，并使用收集的拉曼信号确定分析物浓度。

公开(公告)号：US20130217983A1

公开(公告)日：2013-08-22

申请号：US13731000

申请日：2012-12-29

Applicant: Mihailo V. Rebec ,  Slavko N. Rebec ,  Richard G. Sass

Inventor： Mihailo V. Rebec ,  Slavko N. Rebec ,  Richard G. Sass

IPC: A61B5/1459 ,  A61B5/145

CPC classification number: A61B5/1459 ,  A61B5/14532 ,  Y10T29/49826

Abstract: Embodiments provide analyte sensors, such as implantable analyte sensors, and methods of producing the same. An implantable sensor may include a base with a plurality of chambers. One or more sensor reagents may be retained within the chambers to form analysis regions. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be implanted into the dermis of a subject. One or more of the sensor reagents may exhibit a color change in response to the presence of a target analyte or reaction product thereof. The wavelengths of light reflected from the analysis regions may be detected and analyzed to determine a target analyte concentration. One or more portions of the sensor or components thereof may be configured to facilitate calibration of the sensor, correction of an optical signal obtained from the sensor by a reader device to accommodate variations in the surrounding tissues, and/or calculation of a representative value by a reader device.

Abstract translation: 实施例提供分析物传感器，例如可植入分析物传感器及其生产方法。 可植入传感器可以包括具有多个室的底座。 一个或多个传感器试剂可以保留在室内以形成分析区域。 膜可以通过传感器试剂连接到腔室。 植入式传感器可以植入受试者的真皮中。 一种或多种传感器试剂可以响应于目标分析物或其反应产物的存在而显示出颜色变化。 可以检测和分析从分析区域反射的光的波长以确定目标分析物浓度。 传感器或其组件的一个或多个部分可以被配置为便于传感器的校准，由读取器装置校正由传感器获得的光学信号，以适应周围组织的变化，和/或代表值的计算由 阅读器设备

公开(公告)号：US08452359B2

公开(公告)日：2013-05-28

申请号：US11973790

申请日：2007-10-10

Applicant: Mihailo V. Rebec ,  James E. Smous ,  Steven D. Brown ,  Hu-Wei Tan

Inventor： Mihailo V. Rebec ,  James E. Smous ,  Steven D. Brown ,  Hu-Wei Tan

IPC: A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/726 ,  G01N21/274 ,  G01N21/359 ,  G01N2201/067

Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.

Abstract translation: 用于确定身体组织中的至少一种体液中的分析物的浓度的系统包括红外光源，身体组织界面，检测器和中央处理单元。 身体组织界面适于接触身体组织并将红外光源的光传送到被接触的身体组织。 检测器适于接收对应于通过被分析的身体组织部分透射的红外光的光谱信息，并将接收到的光谱信息转换为指示所接收的光谱信息的电信号。 中央处理单元适于将电信号与建立在体液中与分析物相关的算法进行比较，该算法适于将接收到的光谱信息转换成至少一个体液中分析物的浓度。