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公开(公告)号：US11180521B2
公开(公告)日：2021-11-23
申请号：US16965747
申请日：2019-01-29
IPC分类号： C07H19/048
摘要： Provided herein are compounds of Formula (I) and their salts, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating, for example, diseases or disorders related to aging or stress, diabetes, obesity, mitochondrial diseases, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing.
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公开(公告)号：US10548913B2
公开(公告)日：2020-02-04
申请号：US15877597
申请日：2018-01-23
发明人： Karl D. Normington , David A. Sinclair , David J. Livingston , James M. McKearin , Bruce Szczepankiewicz , Jonathan N. Kremsky
IPC分类号： A01N43/04 , A61K31/70 , A61K31/706 , A61K31/443 , A61K31/661 , C07H19/048 , C07F9/06 , C07F9/547 , C07H11/04 , C07H19/04 , A61K31/7052
摘要： The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
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公开(公告)号：US20240350523A1
公开(公告)日：2024-10-24
申请号：US18516416
申请日：2023-11-21
发明人： Karl D. Normington , David A. Sinclair , David J. Livingston , James M. McKearin , Bruce Szczepankiewicz , Jonathan N. Kremsky
IPC分类号： A61K31/706 , A61K31/443 , A61K31/661 , A61K31/665 , A61K31/7052 , C07F9/06 , C07F9/547 , C07F9/6558 , C07F9/6561 , C07F9/6574 , C07H11/04 , C07H19/04 , C07H19/048
CPC分类号： A61K31/706 , A61K31/443 , A61K31/661 , A61K31/665 , C07F9/06 , C07F9/547 , C07F9/65586 , C07F9/6561 , C07F9/65742 , C07H11/04 , C07H19/048 , A61K31/7052 , C07H19/04
摘要： The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.
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公开(公告)号：US20220144880A1
公开(公告)日：2022-05-12
申请号：US17440849
申请日：2020-03-18
IPC分类号： C07H19/048 , C07H21/02
摘要： The invention relates to compounds and compositions for modulation of nicotinamide adenine dinucleotide (NAD+). The invention also relates to methods of making such compounds and compositions. The invention relates to pharmaceutical compositions containing one or more NAD+ modulating compounds as a first ingredient in combination with one or more active pharmaceutical ingredients. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and/or improving cell and tissue survival.
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公开(公告)号：US20210388019A1
公开(公告)日：2021-12-16
申请号：US17399445
申请日：2021-08-11
IPC分类号： C07H19/048 , A61K9/00 , A61P31/14
摘要： The present disclosure relates to compounds and compositions for use in treating disease, such as viral infection. As disclosed herein, the compounds include an “NMN-like” moiety linked to another moiety with biological activity upon administration. In some cases, the disease to be treated is infection with viruses. Such viruses include coronaviruses, such as SARS, MERS, or COVID-19, HIV, and viruses associated with hepatitis. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD) in cells and tissues for treating diseases and/or improving cell and tissue survival.
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公开(公告)号：US11939348B2
公开(公告)日：2024-03-26
申请号：US17440849
申请日：2020-03-18
IPC分类号： C07H19/048 , C07H21/02
CPC分类号： C07H19/048 , C07H21/02
摘要： The invention relates to compounds and compositions for modulation of nicotinamide adenine dinucleotide (NAD+). The invention also relates to methods of making such compounds and compositions. The invention relates to pharmaceutical compositions containing one or more NAD+ modulating compounds as a first ingredient in combination with one or more active pharmaceutical ingredients. Further, the invention relates to methods of using such compounds or compositions to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and/or improving cell and tissue survival.
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7.发明公开公开(公告)号：US20230257412A1
公开(公告)日：2023-08-17
申请号：US18129345
申请日：2023-03-31
发明人： Jonathan N. Kremsky , Bruce Szczepankiewicz , Karsten Koppetsch , Joseph Harris , Mateusz Pitak , Martin Bates
IPC分类号： C07H19/048 , C07H1/06 , C30B7/02 , A61K31/706
CPC分类号： C07H19/048 , C07H1/06 , C30B7/02 , A61K31/706
摘要： The present disclosure relates to crystalline solids comprising a compound of Formula (I),
wherein R is n-propyl, and methods of making compounds of Formula (I) wherein R is C1-C4 alkyl or C2-C4 alkenyl. The present disclosure also relates to crystalline solids comprising a compound of Formula (II),
The present disclosure further relates to methods of preparing the crystalline solids, and pharmaceutical preparations of the crystalline solids, and use of such pharmaceutical preparations in treatment of diseases and conditions.-
8.发明公开公开(公告)号：US20240109932A1
公开(公告)日：2024-04-04
申请号：US18517380
申请日：2023-11-22
发明人： Jonathan N. Kremsky , Bruce Szczepankiewicz , Karsten Koppetsch , Joseph Harris , Mateusz Pitak , Martin Bates
IPC分类号： C07H19/048 , C30B7/00 , C30B29/54
CPC分类号： C07H19/048 , C30B7/00 , C30B29/54 , C07B2200/13
摘要： The present disclosure relates to crystalline solids comprising a compound of Formula (I),
wherein R is n-propyl, and methods of making compounds of Formula (I) wherein R is C1-C4 alkyl or C2-C4 alkenyl. The present disclosure also relates to crystalline solids comprising a compound of Formula (II),
The present disclosure further relates to methods of preparing the crystalline solids, and pharmaceutical preparations of the crystalline solids, and use of such pharmaceutical preparations in treatment of diseases and conditions.-
公开(公告)号：US20210032280A1
公开(公告)日：2021-02-04
申请号：US16965747
申请日：2019-01-29
IPC分类号： C07H19/048
摘要： Provided herein are compounds of Formula (I) and their salts, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating, for example, diseases or disorders related to aging or stress, diabetes, obesity, mitochondrial diseases, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing.
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10.发明授权公开(公告)号：US11952396B1
公开(公告)日：2024-04-09
申请号：US18517380
申请日：2023-11-22
发明人： Jonathan N. Kremsky , Bruce Szczepankiewicz , Karsten Koppetsch , Joseph Harris , Mateusz Pitak , Martin Bates
IPC分类号： C07H19/048 , C30B7/00 , C30B29/54
CPC分类号： C07H19/048 , C30B7/00 , C30B29/54 , C07B2200/13
摘要： The present disclosure relates to crystalline solids comprising a compound of Formula (I),
wherein R is n-propyl, and methods of making compounds of Formula (I) wherein R is C1-C4 alkyl or C2-C4 alkenyl. The present disclosure also relates to crystalline solids comprising a compound of Formula (II),
The present disclosure further relates to methods of preparing the crystalline solids, and pharmaceutical preparations of the crystalline solids, and use of such pharmaceutical preparations in treatment of diseases and conditions.
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