公开(公告)号：US20240336608A1

公开(公告)日：2024-10-10

申请号：US18617907

申请日：2024-03-27

Applicant: Merck Sharp & Dohme LLC

Inventor： David A. Candito ,  Anthony Donofrio ,  Ronald Dale Ferguson, II ,  George Madalin Giambasu ,  Anmol Gulati ,  Andrew M. Haidle ,  Brett A. Hopkins ,  William P. Kaplan ,  Ping Liu ,  Michaelyn C. Lux ,  Xiao Mei Zheng ,  Ryan D. Otte ,  Alexander Pasternak ,  Elsie C. Yu

IPC: C07D417/14 ,  A61K31/422 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/542 ,  A61K39/395 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D417/14 ,  A61K31/422 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/542 ,  A61K39/3955 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D513/04

Abstract: Described herein are compounds of Formula I




or a pharmaceutically acceptable salt thereof, wherein R1, R2, A, and B are as defined herein. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

公开(公告)号：US20250059220A1

公开(公告)日：2025-02-20

申请号：US18720698

申请日：2022-12-15

Applicant: Merck Sharp & Dohme LLC

Inventor： David A. Candito ,  Matthew L. Childers ,  Duane E. DeMong ,  Christian Fischer ,  Xavier Fradera ,  James P. Jewell ,  Shuhei Kawamura ,  Ping Liu ,  Charles S. Yeung ,  Xiao Mei Zheng ,  Kaitlyn Marie Logan ,  Ryan D. Otte ,  Chunhui Huang ,  Sebastian E. Schneider

IPC: C07F9/6553 ,  A61K31/67 ,  A61K31/675 ,  A61K31/695 ,  A61K45/06 ,  C07F9/6558 ,  C07F9/6561

Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R7 are as defined herein, as well as compositions comprising at least one Substituted Thiophene Derivative, and methods of using the Substituted Thiophene Derivatives for treating or preventing cancer in a patient.