公开(公告)号：US20190389909A1

公开(公告)日：2019-12-26

申请号：US16446940

申请日：2019-06-20

申请人： Merck Sharp & Dohme Corp.

发明人： Harold B. Wood ,  Hubert B. Josien ,  Thomas Joseph Tucker ,  Angela Dawn Kerekes ,  Ling Tong ,  Abbas M. Walji ,  Anilkumar G. Nair ,  Fa-Xiang Ding ,  Elisabetta Bianchi ,  Danila Branca ,  Chengwei Wu ,  Yusheng Xiong ,  Sookhee Nicole HA ,  Jian Liu ,  Sobhana Babu Boga

IPC分类号： C07K7/64 ,  A61P3/06

摘要： Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.