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公开(公告)号：US20190275024A1
公开(公告)日：2019-09-12
申请号：US16396056
申请日：2019-04-26
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , C07D471/20 , A61K31/438 , A61K31/435 , C07D471/10
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20220064147A1
公开(公告)日：2022-03-03
申请号：US17413882
申请日：2019-12-13
发明人： Antonella Converso , Abdellatif El Marrouni , Ashley Forster , Jessica L. Frie , David N. Hunter , Scott D. Kuduk , Helen J. Mitchell , Philippe Nantermet , Deyou Sha , William Daniel Shipe , Cheng Wang , Deping Wang
IPC分类号： C07D403/06 , A61K45/06
摘要： The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
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公开(公告)号：US10272077B2
公开(公告)日：2019-04-30
申请号：US15830131
申请日：2017-12-04
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： C07D471/10 , A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US09499541B2
公开(公告)日：2016-11-22
申请号：US14505255
申请日：2014-10-02
发明人： Ian M. Bell , Mark Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman , Heather E. Stevenson
IPC分类号： A01N43/42 , A61K31/44 , C07D211/00 , C07D213/00 , C07D215/00 , C07D217/00 , C07D219/00 , C07D221/00 , C07D471/04 , A61K31/506 , C07D487/04
CPC分类号： C07D471/04 , A61K31/506 , C07D487/04
摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20150005330A1
公开(公告)日：2015-01-01
申请号：US14485259
申请日：2014-09-12
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20210008055A1
公开(公告)日：2021-01-14
申请号：US16940943
申请日：2020-07-28
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20180092900A1
公开(公告)日：2018-04-05
申请号：US15830131
申请日：2017-12-04
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , C07D471/20 , A61K31/435 , A61K31/438 , C07D471/10
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US09833448B2
公开(公告)日：2017-12-05
申请号：US15293569
申请日：2016-10-14
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A01N43/42 , A61K31/44 , A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20170027925A1
公开(公告)日：2017-02-02
申请号：US15293569
申请日：2016-10-14
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists ofCGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US09499545B2
公开(公告)日：2016-11-22
申请号：US14485259
申请日：2014-09-12
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A01N43/42 , A61K31/44 , C07D211/00 , C07D213/00 , C07D215/00 , C07D217/00 , C07D219/00 , C07D221/00 , C07D471/20 , A61K31/435 , C07D471/10
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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