公开(公告)号：US11946914B2

公开(公告)日：2024-04-02

申请号：US17415091

申请日：2019-12-17

申请人： Merck Patent GmbH

发明人： Pedro Buehner ,  Philipp Knoth ,  Benjamin Peters ,  Michael Ukelis

IPC分类号： G01N30/60 ,  B01D15/22 ,  B22F10/25 ,  B22F10/28 ,  B33Y10/00 ,  B33Y80/00 ,  B22F10/18 ,  B22F10/22

CPC分类号： G01N30/6052 ,  B01D15/22 ,  B22F10/25 ,  B22F10/28 ,  B33Y10/00 ,  B33Y80/00 ,  B22F10/18 ,  B22F10/22

摘要： A method for providing a casing (11) for a prefabricated column (1) of chromatography column material in order to manufacture a chromatography column, wherein the casing (11) is generated by additive manufacturing, includes the steps of rotating the column (1) of chromatography column material with respect to a casing material feed in a manner to successively cover a casing surface (8) of the chromatography column material along a contact area path (12), and of arranging an amount of flowable casing material (9) at a current contact area (7) along the contact area path (12) at the casing surface (8) of the column (1) of chromatography column material in order to generate the casing (11) for the chromatography column by successively adding the solidified amount of casing material (9) at the contact area (7).

公开(公告)号：US20150283090A1

公开(公告)日：2015-10-08

申请号：US14441909

申请日：2013-10-14

申请人： MERCK PATENT GMBH

发明人： Karin Cabrera ,  Ulrich Lang ,  Benjamin Peters ,  Christoph Saal ,  Michael Schulz ,  Dieter Lubda ,  Shawn Kucera

IPC分类号： A61K9/50 ,  A61K47/02 ,  A61K31/216

CPC分类号： A61K9/5031 ,  A61K9/501 ,  A61K9/5089 ,  A61K31/216 ,  A61K47/02

摘要： The present invention is directed to the use of a composite silicon oxide-based material for the modified release of biologically active agents.

摘要翻译： 本发明涉及复合氧化硅基材料用于生物活性剂的改性释放的用途。

公开(公告)号：US10577250B2

公开(公告)日：2020-03-03

申请号：US15346377

申请日：2016-11-08

申请人： Merck Patent GmbH

发明人： Mario Maio ,  Eugenia Breininger ,  Karin Cabrera Perez ,  Ulrich Lang ,  Benjamin Peters ,  Thomas Puchert ,  Christoph Saal ,  Michael Schulz

IPC分类号： A61K9/16 ,  A61K47/02 ,  C01B33/155 ,  C01B33/157 ,  C01B33/18 ,  A61K31/496

摘要： The present invention is directed to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

公开(公告)号：US20170049892A1

公开(公告)日：2017-02-23

申请号：US15346377

申请日：2016-11-08

申请人： Merck Patent GmbH

发明人： Mario Maio ,  Eugenia Breininger ,  Karin Cabrera Perez ,  Ulrich Lang ,  Benjamin Peters ,  Thomas Puchert ,  Christoph Saal ,  Michael Schulz

IPC分类号： A61K47/02 ,  C01B33/18 ,  C01B33/157 ,  A61K31/496 ,  C01B33/155

摘要： The present invention is directed to a process for producing inorganic particulate material, the material obtainable by such process, a modified release delivery system comprising the material and the use of the material for the administration of a bioactive agent.

摘要翻译： 本发明涉及生产无机颗粒材料的方法，可通过这种方法获得的材料，包含该材料的改进释放递送系统和用于施用生物活性剂的材料的使用。