公开(公告)号：US20030228329A1

公开(公告)日：2003-12-11

申请号：US10461030

申请日：2003-06-13

Applicant: Merck & Co., Inc.

Inventor： Ling Chen ,  John W. Shiver ,  Andrew J. Bett ,  Danilo R. Casimiro ,  Michael J. Caulfield ,  Michael A. Chastain ,  Emilio A. Emini

IPC: A61K039/12 ,  C12N007/00 ,  C12N015/867 ,  C12N015/861

CPC classification number: C12N15/86 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12Q1/703

Abstract: An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and boost regime also with a vaccine plasmid.