公开(公告)号：US20030166144A1

公开(公告)日：2003-09-04

申请号：US10303204

申请日：2002-11-25

Applicant: Merck & Co., Inc.

Inventor： Joseph P. Arena ,  Doris F. Cully ,  Scott D. Feighner ,  Andrew D. Howard ,  Paul A. Liberator ,  James M. Schaeffer ,  Leonardus H. T. Van Der Ploeg

IPC: C12P021/02 ,  C07K014/72 ,  C07H021/04 ,  C12N005/06

CPC classification number: C07B59/002 ,  A61K38/00 ,  C07K14/723

Abstract: Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.

公开(公告)号：US20030023074A1

公开(公告)日：2003-01-30

申请号：US10212980

申请日：2002-08-06

Applicant: Merck & Co., Inc.

Inventor： Andrew D. Howard ,  Margaret A. Cascieri ,  Roy G. Smith ,  Kathleen A. Sullivan ,  Carina Tan ,  Leonardus H.T. Van Der Ploeg ,  Kevin R. Lynch

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/705 ,  C07H021/04

CPC classification number: C07K14/72 ,  A61K38/00

Abstract: A new galanin receptor, GALR3, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.

Abstract translation: 描述了一种新的甘丙肽受体GALR3。 还提供了编码相同的核酸和用于鉴定所述受体特异性的配体的各种测定法。 如此鉴定的配体可用于治疗肥胖症，治疗疼痛和治疗认知障碍。