公开(公告)号：US20240109879A1

公开(公告)日：2024-04-04

申请号：US18269901

申请日：2021-12-29

申请人： Medshine Discovery Inc.

发明人： Chunli Shen ,  Yuchuan Zhu ,  Jinxin Liu ,  Chengde Wu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D413/14 ,  C07D417/14

CPC分类号： C07D413/14 ,  C07D417/14

摘要： Provided are a class of benzimidazole compounds and an application thereof as a 300/CBP inhibitor. Specifically, provided are a compound represented by formula (P) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US11702400B2

公开(公告)日：2023-07-18

申请号：US17767104

申请日：2020-10-16

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun Wu ,  Zheming Xiao ,  Chunyan Jiang ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/13

摘要： Salt types, crystal forms, and preparation methods for benzopyrazole compounds as RHO kinase inhibitors. Specifically, disclosed are hydrochloride and acetate of compounds of formula (I) and crystal forms thereof, as well as application of the salt types and the crystal forms in preparation of RHO inhibitor drugs.

公开(公告)号：US11377444B2

公开(公告)日：2022-07-05

申请号：US16760740

申请日：2018-11-02

申请人： MEDSHINE DISCOVERY INC.

发明人： Kevin X Chen ,  Zhaoguo Chen ,  Li Zhang ,  Yanxin Yu ,  Kai Zhou ,  Boyu Hu ,  Xiaofei Wang ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D519/00

摘要： Disclosed are a series of pyridopyrimidine compounds and a use of same in the preparation of drugs associated with mTORC 1/2 dual complex inhibitors, and specifically disclosed is a use of the compounds as shown in formula (IV), tautomers thereof or pharmaceutically acceptable salts thereof in the preparation of drugs associated with mTORC 1/2 dual complex inhibitors.

公开(公告)号：US11299475B2

公开(公告)日：2022-04-12

申请号：US16967546

申请日：2019-02-02

申请人： MEDSHINE DISCOVERY INC.

发明人： Wenyuan Qian ,  Chundao Yang ,  Guanghai Xu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D401/14 ,  A61P9/12 ,  C07D241/20 ,  C07D401/04 ,  C07D417/14

摘要： A compound represented by formula (I) or an isomer or a pharmaceutically acceptable salt thereof. The present invention also relates to an application of the same in preparing a drug for treating a disease related to a PGI2 receptor.

公开(公告)号：US20190062338A1

公开(公告)日：2019-02-28

申请号：US15999075

申请日：2017-02-20

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Medshine Discovery Inc.

发明人： Shilan Liu ,  Dahai Wang ,  Guibai Liang ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D487/14 ,  C07D495/14 ,  C07D519/00

摘要： Provided are compounds of formula I and formula II or pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The compounds of formula I and formula II or the pharmaceutically acceptable salts of the compounds provide indole 2,3-dioxygenase (IDO) inhibitory activity and are capable of treating IDO-mediated immunosuppressive diseases, such as infectious diseases or cancer.

公开(公告)号：US11680070B2

公开(公告)日：2023-06-20

申请号：US15734906

申请日：2019-06-05

申请人： MEDSHINE DISCOVERY INC.

发明人： Xiaoping Zheng ,  Zhigan Jiang ,  Haiying He ,  Jie Li ,  Zhen Gong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D495/04 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P17/10 ,  A61P35/00 ,  A61K31/522

CPC分类号： C07D495/04 ,  A61P1/16

摘要： Disclosed are a thieno[2,3-c]pyridazin-4(1H)-one derivative as an ACC1 or ACC2 inhibitor and an application thereof in preparing a drug as an ACC1 or ACC2 inhibitor. In particular, disclosed is a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

公开(公告)号：US11623923B2

公开(公告)日：2023-04-11

申请号：US16766510

申请日：2018-11-23

申请人： MEDSHINE DISCOVERY, INC.

发明人： Jinping Li ,  Xiongbin Xu ,  Gang Li ,  Lihong Hu ,  Charles Z. Ding ,  Yaling Zhou ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61P35/00 ,  C07D405/14 ,  C07D487/04

摘要： Provided are a uracil compound represented by Formula (IV) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition of the same. Also provided is a use thereof as a c-MET/AXL inhibitor in preparing a c-MET/AXL-inhibiting drug or a drug for treating a tumor.

公开(公告)号：US11345678B2

公开(公告)日：2022-05-31

申请号：US17047840

申请日：2019-04-18

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun Wu ,  Jun Yin ,  Cailin Wang ,  Zheming Xiao ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D403/04 ,  C07D403/12 ,  C07D401/04 ,  A61P11/00 ,  C07D231/56

摘要： The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

公开(公告)号：US11319330B2

公开(公告)日：2022-05-03

申请号：US17274236

申请日：2019-09-09

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi Lei ,  Yunfu Luo ,  Yu Xu ,  Guoli Zhang ,  Jinghong Dong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D405/04 ,  C07D405/12 ,  C07D513/04 ,  C07D491/048 ,  C07D498/04 ,  A61P35/00

摘要： Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11192886B2

公开(公告)日：2021-12-07

申请号：US16319491

申请日：2017-07-21

申请人： MEDSHINE DISCOVERY INC.

发明人： Lingyun Wu ,  Peng Zhang ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D409/04 ,  C07D513/04 ,  C07D487/04 ,  C07D209/58 ,  C07D417/14

摘要： The present invention relates to a class of tricyclic compounds and an application thereof as a sphingosine 1-phosphate type 1 (S1P1) receptor agonist. The invention specifically relates to a compound represented by formula (II), and a tautomer and pharmaceutically acceptable salt of same.